Target Name: RNF180
NCBI ID: G285671
Review Report on RNF180 Target / Biomarker Content of Review Report on RNF180 Target / Biomarker
RNF180
Other Name(s): RING finger protein 180 | E3 ubiquitin-protein ligase RNF180 | ring finger protein 180 | RN180_HUMAN | Ring finger protein 180 | RING-type E3 ubiquitin transferase RNF180 | E3 ubiquitin-protein ligase RNF180 (isoform 1) | RINES | RNF180 variant 1 | Ring finger protein 180, transcript variant 1

Understanding The Role of RFP180 in RNA-Protein Interactions

The RING finger protein 180 (RNF180) is a protein that is expressed in various tissues of the body, including the brain, heart, liver, and kidneys. It is a member of the superfamily of RNA-protein hybrids, which are involved in various cellular processes. One of the unique features of RFP180 is its ability to interact with small nucleolar RNA (snRNA), which is a crucial molecule in the regulation of gene expression.

The Importance of RNA-Protein Interactions

RNA-protein interactions are a crucial aspect of gene regulation, as they allow the cell to sense and respond to various signaling cues. The interaction between RFP180 and snRNA is of particular interest, as it allows the protein to regulate gene expression. This is important for the development and maintenance of various cellular processes, including cell growth, apoptosis, and inflammation.

Drug Targeting and Biomarker

Due to its unique ability to interact with snRNA, RFP180 has potential as a drug target. One of the goals of drug development is to identify small molecules that can modulate gene expression and treat various diseases. By targeting RFP180, researchers may be able to develop new treatments for a variety of conditions.

Another potential use of RFP180 is as a biomarker for certain diseases. The expression of RFP180 has been shown to be elevated in a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. This suggests that RFP180 may be a useful biomarker for these conditions.

Expression and Functions of RFP180

RNA-protein interactions are a common occurrence in various organisms, including humans. The expression of RFP180 has been shown to be elevated in a variety of tissues and cells, including the brain, heart, liver, and kidney.

In the brain, RFP180 has been shown to play a role in the regulation of synaptic plasticity, which is the ability of the brain to change and adapt over time. In addition, RFP180 has been shown to be involved in the regulation of neuronal excitability, which is important for the proper functioning of the brain.

In the heart, RFP180 has been shown to play a role in the regulation of cardiac contractility and heart rate. In addition, the protein has been shown to interact with the transcription factor p300, which is involved in the regulation of cardiac gene expression.

In the liver, RFP180 has been shown to play a role in the regulation of metabolism and inflammation. The protein has been shown to interact with the transcription factor NF-kappa-B, which is involved in the regulation of inflammation and metabolism.

In the kidney, RFP180 has been shown to play a role in the regulation of water and electrolyte balance. The protein has been shown to interact with the transcription factor IRX, which is involved in the regulation of water and electrolyte balance.

Conclusion

RNA-protein interactions are a crucial aspect of gene regulation, and the interaction between RFP180 and snRNA is of particular interest. The protein's ability to regulate gene expression makes it a potential drug target, and its potential as a biomarker for various diseases makes it an important tool for the development of new treatments. Further research is needed to fully understand the role of RFP180 in various cellular processes and its potential as a drug target and biomarker.

Protein Name: Ring Finger Protein 180

Functions: E3 ubiquitin-protein ligase which promotes polyubiquitination and degradation by the proteasome pathway of ZIC2

The "RNF180 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about RNF180 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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