CPSF1: A Protein Regulating Gene Expression and DNA Replication

Target Name: CPSF1

NCBI ID: G29894

CPSF1

CPSF1: A Protein Regulating Gene Expression and DNA Replication

CPSF1 (Cleavage and polyadenylation specific factor 1) is a protein that plays a critical role in the regulation of gene expression and DNA replication in various organisms, including humans. It is a key factor in the process of transcription, where RNA is produced from DNA, and it is involved in the recruitment of various proteins to the RNA polymerase complex. CPSF1 is also involved in the regulation of polygenesis, where new genes are created.

CPSF1 is a protein that consists of 130 amino acids and has a molecular weight of 13.9 kDa. It is a single-stranded protein that contains a N-terminus, a catalytic domain, and a C-terminus. The N-terminus of CPSF1 contains a putative N-endonuclease domain, which is responsible for the cleavage of DNA by the protein. The catalytic domain of CPSF1 contains a single transmembrane alpha-helix that is responsible for the binding of CPSF1 to the RNA polymerase complex. The C-terminus of CPSF1 contains a single amino acid residue that is responsible for the polygenesis-specific function of the protein.

CPSF1 is involved in the regulation of gene expression and DNA replication in various organisms, including bacteria, archaea, and eukaryotes. In bacteria, CPSF1 is involved in the regulation of bacterial DNA replication, where it plays a critical role in the replication of the chromosome X in bacterial cells. In archaea, CPSF1 is involved in the regulation of gene expression and DNA replication, where it is involved in the transcription of gene arrays. In eukaryotes, CPSF1 is involved in the regulation of gene expression and DNA replication, where it is involved in the transcription and translation of gene products.

CPSF1 is also involved in the regulation of polygenesis in various organisms. In bacteria, CPSF1 is involved in the regulation of gene expression and DNA replication, where it is involved in the transcription and translation of gene products. In archaea, CPSF1 is involved in the regulation of gene expression and DNA replication, where it is involved in the transcription of gene arrays. In eukaryotes, CPSF1 is involved in the regulation of gene expression and DNA replication, where it is involved in the transcription and translation of gene products.

CPSF1 is a protein that has been identified as a potential drug target in various organisms. Its involvement in the regulation of gene expression and DNA replication makes it an attractive target for small molecules that can be used to inhibit its activity. CPSF1 has been shown to play a role in the regulation of cancer progression, where it is involved in the regulation of cancer cell growth and survival.

In conclusion, CPSF1 is a protein that plays a critical role in the regulation of gene expression and DNA replication in various organisms. Its involvement in the regulation of polygenesis makes it an attractive target for small molecules that can be used to inhibit its activity. Further research is needed to fully understand the role of CPSF1 in the regulation of gene expression and DNA replication.

Protein Name: Cleavage And Polyadenylation Specific Factor 1

Functions: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction (PubMed:14749727). May play a role in eye morphogenesis and the development of retinal ganglion cell projections to the midbrain (By similarity)

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