ANAPC4: Role in Cell Division and Potential Drug Target (G29945)

Target Name: ANAPC4

NCBI ID: G29945

ANAPC4

ANAPC4: Role in Cell Division and Potential Drug Target

ANAPC4, also known as Anaphase-promoting complex subunit 4 (isoform 2), is a protein that plays a critical role in the process of cell division. It is a subunit of the Anaphase-promoting complex (APC), which is a complex of proteins that help ensure the proper execution of cell division during the process of mitosis.

APC is composed of several subunits, including ANAPC2, ANAPC3, and ANAPC4. ANAPC4 is one of the most well-studied subunits, and its function in cell division has been extensively investigated.

One of the key functions of ANAPC4 is its role in the initiation of anaphase. During anaphase, the chromosomes are replicated and the daughter chromatin is produced. ANAPC4 is involved in the recruitment of the chromatin fiber to the centromere, which is the protein structure on the mitotic spindle that pulls the chromosomes to ends opposite during anaphase.

In addition to its role in initiating anaphase, ANAPC4 is also involved in the regulation of the stability of the chromatin fiber. Chromatin fibers are composed of microtubules of the protein Tubulin, which help to keep the chromosomes in a condensed state during interphase . ANAPC4 helps to regulate the stability of these fibers by interacting with the microtubules and preventing them from being disrupted.

ANAPC4 is also involved in the regulation of the entry of new chromatin fibers into the mitotic spindle. This process is called spindle organization, and it is critical for ensuring that each chromosome is correctly aligned at the centromere during anaphase. ANAPC4 helps to regulate the amount of new chromatin fibers that enter the spindle, which is determined by the level of ANAPC4 itself.

ANAPC4 is also involved in the regulation of the stability of the nuclear envelope. During interphase, the nuclear envelope helps to protect the chromosomes from the intracellular environment and also helps to maintain the correct shape of the chromosomes. ANAPC4 is involved in the regulation of the stability of this envelope, by interacting with the nuclear envelope-associated protein NEDD8.

ANAPC4 is a protein that plays a critical role in the process of cell division, and it is a potential drug target or biomarker. Many studies have investigated the function of ANAPC4, and several potential small molecules have been shown to interact with this protein. These Small molecules are being used to develop new treatments for a variety of diseases, including cancer, neurodegenerative diseases, and developmental disorders.

In conclusion, ANAPC4 is a protein that plays a critical role in the process of cell division. It is involved in the initiation of anaphase, the regulation of the stability of the chromatin fiber, the entry of new chromatin fibers into the

Protein Name: Anaphase Promoting Complex Subunit 4

Functions: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains

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