HMGB2: Potential Drug Targets in Cell Signaling, Adhesion, Migration, DNA Replication and Cell Survival

Target Name: HMGB2

NCBI ID: G3148

HMGB2

HMGB2: Potential Drug Targets in Cell Signaling, Adhesion, Migration, DNA Replication and Cell Survival

HMGB2, also known as high mobility group protein 2, is a protein that is expressed in various tissues throughout the body. It is a member of the high mobility group protein (HMG) family, which includes a variety of proteins that are involved in various cellular processes, including signaling, DNA replication, and transport. One of the key functions of HMGB2 is its role in cell signaling, particularly in the regulation of cell adhesion and migration.

HMGB2 is a 21-kDa protein that is expressed in a variety of tissues, including muscle, bone, liver, and heart. It is highly mobile, which allows it to participate in various cellular processes that require its structural integrity. HMGB2 has a number of unique features that make it an attractive potential drug target.

One of the key advantages of HMGB2 is its ability to interact with a variety of signaling molecules. This interactivity makes it a potentially useful target for drugs that are designed to modulate cellular signaling pathways. For example, HMGB2 has been shown to interact with a variety of signaling molecules, including TGF-β, NF-kappa-B, and PI3K. This interactivity makes it a potentially useful target for drugs that are designed to inhibit these signaling pathways.

Another advantage of HMGB2 is its role in cell adhesion and migration. HMGB2 is a key component of the cytoskeleton, which is the structure that gives cells shape and stability. In addition, HMGB2 is involved in the regulation of cell adhesion, which is important for the proper functioning of tissues and organs. This role makes HMGB2 an potentially useful target for drugs that are designed to modulate cell adhesion and migration.

In addition to its role in cell signaling and adhesion, HMGB2 is also involved in the regulation of DNA replication. This function is important for the proper functioning of cells, as it ensures that new genetic information is passed on to the next generation. HMGB2 is also involved in the regulation of DNA replication in response to damage, which makes it an potentially useful target for drugs that are designed to prevent or repair DNA damage.

Another potential advantage of HMGB2 is its role in the regulation of cell survival. This function is important for the proper functioning of cells, as it ensures that they are able to survive and continue to function in the face of various challenges. HMGB2 is also involved in the regulation of cell survival in response to stress, which makes it an potentially useful target for drugs that are designed to prevent or repair cellular damage.

In conclusion, HMGB2 is a protein that is involved in a variety of cellular processes that are important for the proper functioning of tissues and organs. Its ability to interact with signaling molecules and participate in cell signaling, adhesion, and migration makes it an potentially useful drug target. In addition, HMGB2 is also involved in the regulation of DNA replication and cell survival, which makes it another potentially useful target for drugs that are designed to prevent or repair cellular damage. Further research is needed to fully understand the role of HMGB2 in these processes and to identify potential drug targets.

Protein Name: High Mobility Group Box 2

Functions: Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J recombination and probably other processes. Binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity (PubMed:7797075, PubMed:11909973, PubMed:19522541, PubMed:18413230, PubMed:19965638, PubMed:20123072). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (By similarity). Proposed to be involved in the innate immune response to nucleic acids by acting as a promiscuous immunogenic DNA/RNA sensor which cooperates with subsequent discriminative sensing by specific pattern recognition receptors (By similarity). In the extracellular compartment acts as a chemokine. Promotes proliferation and migration of endothelial cells implicating AGER/RAGE (PubMed:19811285). Has antimicrobial activity in gastrointestinal epithelial tissues (PubMed:23877675). Involved in inflammatory response to antigenic stimulus coupled with pro-inflammatory activity (By similarity). Involved in modulation of neurogenesis probably by regulation of neural stem proliferation (By similarity). Involved in articular cartilage surface maintenance implicating LEF1 and the Wnt/beta-catenin pathway (By similarity)

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•   general information;
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•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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