HMGN1P37: A Non-Histone Protein Regulating Gene Expression and DNA Replication

Target Name: HMGN1P37

NCBI ID: G728776

HMGN1P37

Other Name(s): high mobility group nucleosome binding domain 1 pseudogene 37 | High mobility group nucleosome binding domain 1 pseudogene 37

HMGN1P37: A Non-Histone Protein Regulating Gene Expression and DNA Replication

High mobility group nucleosome binding domains (HMGNs) are a family of non-histone proteins that play a crucial role in the regulation of gene expression and DNA replication. HMGNs are also known as nucleosome binding proteins (NBP) and are involved in the organization and dynamics of nucleosomes, which are the basic units of chromatin. The HMGN1P37 gene, located on chromosome 19, has been identified as a pseudogene that is not highly expressed in humans. However, its potential role in the regulation of gene expression and cancer development makes it an attractive target for further research.

Expression and Localization

HMGN1P37 is a 17 kDa protein that is expressed in a variety of tissues and organs, including brain, heart, lung, and gastrointestinal tract. It is predominantly expressed in the brain, where it is found in the cytoplasm and in the endoplasmic reticulum (ER). The protein is also expressed in other tissues, including muscle and pancreas, at lower levels.

The protein is localized to the nuclear envelope, where it interacts with various nuclear proteins, including histone modifications and histone-protein interactions. It is also involved in the organization of the nuclear envelope and in the regulation of gene expression.

Function and Interaction

HMGN1P37 plays a critical role in the regulation of gene expression and DNA replication. It is a component of the nucleosome, which is the basic unit of chromatin. The nucleosome is composed of a protein complex called histone, which is modified with various post-translational modifications, including acetylation and methylation. These modifications play a crucial role in the regulation of gene expression and DNA replication.

HMGN1P37 is involved in the regulation of DNA replication, as it is able to interact with the DNA replication machinery. It has been shown that the HMGN1P37 protein is highly localizable to the nuclear envelope, which is the outermost layer of the nuclear membrane. This localization is important for the regulation of DNA replication, as it allows the protein to interact with the DNA replication machinery.

In addition to its role in DNA replication, HMGN1P37 is also involved in the regulation of gene expression. It is able to interact with various nuclear proteins, including histone modifications and histone-protein interactions. These interactions play a crucial role in the regulation of gene expression, as they allow the protein to interact with the target genes and regulate their translation into protein.

Drug Targets and Cancer Theories

HMGN1P37 has been identified as a potential drug target for the treatment of various diseases, including cancer. The high mobility group nucleosome binding domain is a unique feature that makes HMGN1P37 an attractive target for small molecules. Small molecules can bind to the HMGN1P37 protein and alter its localization, which could lead to changes in gene expression and cellular behavior.

In addition to its potential as a drug target, HMGN1P37 has also been studied in the context of cancer. It has been shown that HMGN1P37 is overexpressed in various types of cancer, including breast, ovarian, and colorectal cancer. This overexpression is thought to contribute to the development and progression of these diseases.

Conclusion

HMGN1P37 is a non-histone protein that plays a crucial role in the regulation of gene expression and DNA replication. Its localization to the nuclear envelope and its interactions with various nuclear proteins make it an attractive target for small molecules. In addition to its potential as a drug target, HMGN1P37 has also been studied in the context of cancer. Further research is needed to fully understand the role of HMGN1P37 in the regulation of gene expression and the development and progression of cancer.

Protein Name: High Mobility Group Nucleosome Binding Domain 1 Pseudogene 37

The "HMGN1P37 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about HMGN1P37 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets