HNF1B: A Key Regulator of Nuclear Factor (NF) Signaling (G6928)

Target Name: HNF1B

NCBI ID: G6928

HNF1B

HNF1B: A Key Regulator of Nuclear Factor (NF) Signaling

HNF1B (HNF1B_HUMAN), a gene that encodes a protein known as the Homeobox gene family protein HNF1B, is a key regulator of nuclear factor (NF) signaling. HNF1B plays a crucial role in the development and maintenance of tissues, including neural cells, and is involved in a wide range of physiological processes, including cell growth, differentiation, and survival.

The HNF1B gene has four known splice variants, HNF1B1, HNF1B2, HNF1B3, and HNF1B4. All of these variants encode a protein that has a similar structure and function, but varies in its length and/or its presence. HNF1B1 is the most abundant of the four variants and is widely expressed in various tissues and organs, including brain, heart, and muscle.

HNF1B is involved in a number of different signaling pathways, including the Wnt signaling pathway, the TGF-灏? pathway, and the NF-kappa-B pathway. These signaling pathways play important roles in the development and maintenance of tissues and organs, and are often disrupted in various diseases, including cancer, neurodegenerative diseases, and developmental disorders.

One of the key functions of HNF1B is its ability to regulate the activity of NF signaling pathways. NF signaling pathways are a complex set of intracellular signaling pathways that involve the recruitment of various transcription factors to their target genes, as well as the formation of signaling complexes that regulate the expression of these genes. HNF1B is involved in the regulation of several key NF signaling pathways, including the Wnt pathway, the TGF-灏? pathway, and the NF-kappa-B pathway.

The Wnt pathway is a well-established signaling pathway that is involved in the development and maintenance of tissues, including neural cells. HNF1B is known to play a role in the regulation of Wnt signaling by recruiting the transcription factor SMAD2, which is critical for the development of neural stem cells.

The TGF-灏? pathway is also a well-established signaling pathway that is involved in the development and maintenance of tissues, including neural cells. HNF1B is known to play a role in the regulation of TGF-灏? signaling by recruiting the transcription factor TGF-灏?1, which is critical for the development and maintenance of neural cells.

The NF-kappa-B pathway is also a well-established signaling pathway that is involved in the regulation of inflammation, pain, and other physiological processes. HNF1B is known to play a role in the regulation of NF-kappa-B signaling by recruiting the transcription factor NF-kappa-B1, which is critical for the production of pro-inflammatory cytokines.

In conclusion, HNF1B is a key regulator of several different signaling pathways that play important roles in the development and maintenance of tissues and organs. Its regulation of these signaling pathways is often disrupted in various diseases, including cancer, neurodegenerative diseases, and developmental disorders. Therefore, HNF1B is a potential drug target and a biomarker for a variety of diseases.

Protein Name: HNF1 Homeobox B

Functions: Transcription factor that binds to the inverted palindrome 5'-GTTAATNATTAAC-3' (PubMed:7900999, PubMed:17924661). Binds to the FPC element in the cAMP regulatory unit of the PLAU gene (By similarity). Transcriptional activity is increased by coactivator PCBD1 (PubMed:24204001)

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•   general information;
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•   expression level;
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•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
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