HMGCR: Enzyme Plays A Crucial Role in Saturated Fatty Acid Metabolism

Target Name: HMGCR

NCBI ID: G3156

HMGCR

Other Name(s): Hydroxymethylglutaryl CoA reductase (NADPH) | HMGCoA reductase-mevalonate | HMDH_HUMAN | NADP-oxidoreductase (acetylating-CoA) | S-3-hydroxy-3-methylglutaryl-CoA reductase | Beta-hydroxy-beta-methylglutaryl coenzyme A reductase | HMG-CoA reductase | 3-hydroxy-3-methylglutaryl-CoA reductase | Hydroxymethylglutaryl coenzyme A reductase (reduced nicotinamide adenine dinucleotide phosphate) | Hydroxymethylglutaryl-CoA reductase | NADPH-hydroxymethylglutaryl-CoA reductase | Hydroxymethylglutaryl-CoA reductase (NADPH2) | 3-hydroxy-3-methylglutaryl CoA reductase (NADPH) | LDLCQ3 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 3-hydroxy-3-methylglutaryl-coenzyme A reductase (isoform 1) | HMGCR variant 1 | 3-hydroxy-3-methylglutaryl-Coenzyme A reductase | 3-hydroxy-3-methylglutaryl-CoA reductase, transcript variant 1 | hydroxymethylglutaryl-CoA reductase

HMGCR: Enzyme Plays A Crucial Role in Saturated Fatty Acid Metabolism

HMGCR, or Hydroxymethylglutaryl CoA reductase, is a enzyme that plays a crucial role in the metabolism of saturated fatty acids, which are found in many foods, including meat, butter, and dairy products. The body needs to maintain the balance of beneficial and harmful fats in order to function properly, and the HMGCR enzyme helps to keep the levels of these fats in check.

HMGCR is a protein that is located in the liver and is responsible for breaking down a type of fat called triacylglycerol. This fat is a common component of many foods and is found in high levels in foods that are high in saturated and trans fats. When HMGCR is active, it converts triacylglycerol into a type of fat called mevalonate, which is then used by the body for energy or storage.

One of the key roles of HMGCR is to regulate the levels of saturated fatty acids in the body. When levels of saturated fatty acids become too high, they can contribute to a number of health problems, including the development of heart disease and certain cancers. To keep the levels of saturated fatty acids under control, HMGCR helps to break down these fats and convert them into more healthy types of fats.

Another important role of HMGCR is to produce NADPH, or NAD+ reactive phosphate, which is a crucial co-factor for many enzymes in the body. NADPH is involved in the metabolism of fats, as well as a variety of other nutrients, and is essential for the growth and development of new cells.

The potential drug target for HMGCR is related to its role in the production of NADPH, as HMGCR has been shown to play a key role in the production of this co-factor. Studies have suggested that inhibiting HMGCR may be a useful way to boost the production of NADPH and potentially improve the health benefits of certain treatments.

In addition to its role in NADPH production, HMGCR is also a potential biomarker for a number of diseases. For example, individuals with certain genetic variations in the HMGCR gene have been shown to have an increased risk of developing heart disease and certain cancers. By targeting HMGCR as a drug target, researchers may be able to develop new treatments for these diseases.

Overall, HMGCR is a complex enzyme that plays a crucial role in the metabolism of saturated fatty acids and the production of NADPH. Its potential as a drug target and biomarker make it an attractive target for researchers and clinicians who are working to improve the health and treatment options for a variety of diseases.

Protein Name: 3-hydroxy-3-methylglutaryl-CoA Reductase

Functions: Catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular cholesterol homeostasis (PubMed:2991281, PubMed:21357570, PubMed:6995544). HMGCR is the main target of statins, a class of cholesterol-lowering drugs (PubMed:11349148, PubMed:18540668)

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