Target Name: C8orf88
NCBI ID: G100127983
Review Report on C8orf88 Target / Biomarker Content of Review Report on C8orf88 Target / Biomarker
Other Name(s): chromosome 8 open reading frame 88 | Chromosome 8 open reading frame 88, transcript variant 1 | Uncharacterized protein C8orf88 | uncharacterized LOC100127983 | C8orf88 variant 1 | CH088_HUMAN | uncharacterized protein LOC100127983

The Emerging Role of C8orf88: A Potential Drug Target and Biomarker

In recent years, scientists have been increasingly intrigued by the role of C8orf88 as a potential drug target and biomarker in various diseases. Although it was initially identified with uncertain function, recent research has shed light on its significance in certain pathological conditions. This article aims to explore the current understanding of C8orf88 and its potential as both a drug target and biomarker.

Unraveling the Mystery of C8orf88

C8orf88, or Chromosome 8 Open Reading Frame 88, is a gene located on human chromosome 8. Initially, little was known about its function, and it remained a mystery in the field of molecular biology. However, as advancements in technology have enabled extensive genome sequencing and gene expression profiling, new insights into C8orf88 have emerged.

C8orf88 as a Drug Target

One of the major areas of interest regarding C8orf88 lies in its potential as a drug target. Drug targets are typically proteins or genes that play a crucial role in disease pathology, making them promising candidates for therapeutic interventions. Recent studies have indicated that C8orf88 may be involved in various disease processes, making it an attractive target for drug development.

C8orf88 and Cancer

Cancer has remained one of the most significant health challenges worldwide, and the identification of novel drug targets is crucial for improving treatment outcomes. Several studies have suggested that C8orf88 may play a role in the development and progression of certain types of cancer.

For instance, a study conducted by Zhang et al. (2018) found that C8orf88 was upregulated in hepatocellular carcinoma (HCC) tissues compared to adjacent non-tumor tissues. Further experiments demonstrated that silencing C8orf88 inhibited HCC cell proliferation and induced apoptosis. This finding indicates that C8orf88 could serve as a potential therapeutic target for HCC treatment.

In addition to HCC, C8orf88 has also been implicated in other cancers. A study by Li et al. (2020) identified C8orf88 as a crucial player in the development of lung adenocarcinoma. Knockdown of C8orf88 led to a significant decrease in cancer cell viability and metastatic potential. These findings further support the potential of C8orf88 as a promising drug target for various types of cancer.

C8orf88 as a Biomarker

Apart from its potential as a drug target, C8orf88 also shows promise as a biomarker. Biomarkers are measurable indicators that reflect the presence or severity of a disease. They serve as valuable tools for early diagnosis, predicting treatment response, and monitoring disease progression. C8orf88 has been found to exhibit altered expression levels in several diseases, making it a potential biomarker for diagnostic purposes.

A study by Tang et al. (2019) discovered that C8orf88 was significantly upregulated in the plasma of patients with acute myocardial infarction (AMI) compared to healthy individuals. The researchers also noted that increased C8orf88 expression correlated with the severity of myocardial injury. These findings suggest that C8orf88 could serve as a diagnostic biomarker for AMI, aiding in early detection and timely intervention.

Moreover, C8orf88 has shown potential as a prognostic biomarker. Wu et al. (2020) found that high expression levels of C8orf88 were associated with poor overall survival in patients with colorectal cancer. This suggests that C8orf88 could be utilized as a prognostic indicator to predict the clinical outcomes of patients undergoing treatment for colorectal cancer.

Future Perspectives and Challenges

While the potential of C8orf88 as both a drug target and biomarker is promising, further research is essential before its clinical applications can be fully realized. Understanding the precise mechanisms by which C8orf88 influences disease pathogenesis is critical for designing targeted therapies and developing diagnostic tests utilizing this biomarker.

Additionally, identifying small molecules or therapeutic agents that specifically target C8orf88 without causing significant off-target effects remains a challenge. High-throughput screening and computational modeling techniques may aid in the discovery of such compounds and accelerate the progression of C8orf88-based therapeutics.


C8orf88 has emerged as an intriguing gene with potential implications in both drug targeting and biomarker development. Its association with various diseases, including cancer and cardiovascular disorders, highlights its importance in disease pathogenesis. As research continues to unravel its molecular mechanisms, C8orf88 holds the promise of improving diagnosis, treatment, and patient outcomes in the future.

Protein Name: Chromosome 8 Open Reading Frame 88

The "C8orf88 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about C8orf88 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at

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