LRRC8D: A Potential Drug Target and Biomarker (G55144)

Target Name: LRRC8D

NCBI ID: G55144

LRRC8D

LRRC8D: A Potential Drug Target and Biomarker

Leucine rich repeat containing 8 (LRRC8D) is a protein that is expressed in various tissues of the body, including the brain, heart, and gastrointestinal tract. It is characterized by the presence of a specific repeat sequence that is composed of 8 leucine residues that are repeated in a specific order.

The function of LRRC8D is not well understood, but it is thought to play a role in various cellular processes, including cell signaling, protein synthesis, and stress response. LRRC8D is also expressed in various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

Drug targeting

LRRC8D has been identified as a potential drug target in various diseases. One of the main reasons for this is the presence of the LRRC8D repeat sequence, which makes it a target for small molecules that can interact with this region.

Studies have shown that LRRC8D is a good candidate for drug targeting due to its high stability and the presence of multiple conserved amino acid residues that are involved in protein-protein interactions. LRRC8D has been shown to interact with various protein partners, including the protein heat shock protein (Hsp90), which plays a role in protein folding and stability.

Another potential mechanism for LRRC8D drug targeting is its role in cellular signaling pathways. LRRC8D has been shown to be involved in various signaling pathways, including the TGF-β pathway, which plays a role in cell growth, differentiation, and stress response.

Biomarker

LRRC8D has also been identified as a potential biomarker for various diseases. The LRRC8D repeat sequence is unique in that it is highly conserved across different species, which makes it a good candidate for use as a biomarker.

Studies have shown that LRRC8D is expressed in various tissues of the body and that it is highly stable in the presence of various diseases. This suggests that LRRC8D could be used as a biomarker for diseases such as cancer, neurodegenerative diseases, and autoimmune disorders.

Conclusion

LRRC8D is a protein that has been identified as a potential drug target due to its unique repeat sequence and the potential role it plays in various cellular processes. Studies have also shown that LRRC8D is a potential biomarker for various diseases. Further research is needed to fully understand the function of LRRC8D and its potential as a drug target and biomarker.

Protein Name: Leucine Rich Repeat Containing 8 VRAC Subunit D

Functions: Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24790029, PubMed:26530471, PubMed:26824658, PubMed:28193731, PubMed:32415200). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (PubMed:24790029, PubMed:26824658, PubMed:28193731). Plays a redundant role in the efflux of amino acids, such as aspartate, in response to osmotic stress (PubMed:28193731). LRRC8A and LRRC8D are required for the uptake of the drug cisplatin (PubMed:26530471). Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:24782309, PubMed:24790029, PubMed:26824658, PubMed:28193731). Also acts as a regulator of glucose-sensing in pancreatic beta cells: VRAC currents, generated in response to hypotonicity- or glucose-induced beta cell swelling, depolarize cells, thereby causing electrical excitation, leading to increase glucose sensitivity and insulin secretion (By similarity). VRAC channels containing LRRC8D inhibit transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol (PubMed:33171122). Mediates the import of the antibiotic blasticidin-S into the cell (PubMed:24782309)

The "LRRC8D Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about LRRC8D comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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