Understanding The LRRC8E Subunit: A Key Protein in Ion Channel Regulation

Target Name: LRRC8E

NCBI ID: G80131

LRRC8E

Other Name(s): Volume-regulated anion channel subunit LRRC8E | leucine-rich repeat-containing protein 8E | LRRC8E variant 1 | Volume-regulated anion channel subunit LRRC8E (isoform 1) | leucine rich repeat containing 8 VRAC subunit E | leucine rich repeat containing 8 family member E | Leucine rich repeat containing 8 VRAC subunit E, transcript variant 2 | LRC8E_HUMAN | LRRC8E variant 2 | leucine rich repeat containing 8 family, member E | Leucine rich repeat containing 8 VRAC subunit E, transcript variant 1

Understanding The LRRC8E Subunit: A Key Protein in Ion Channel Regulation

The LRRC8E subunit is a protein that is expressed in various tissues and cells in the human body. It is a key component of the voltage-regulated anion channel (VAC) family, which is a channel that is involved in the regulation of ion channels in various cell types. The LRRC8E subunit is responsible for the regulation of the VAC, which is a critical channel that is involved in the transport of a variety of ions, including ions of importance such as calcium, magnesium, and potassium.

The LRRC8E subunit is found in many different tissues and cells throughout the body, including the heart, the kidneys, the liver, and the pancreas. It is expressed in various cell types, including muscle cells, nerve cells, and epithelial cells. The LRRC8E subunit is also expressed in the placenta, which is the tissue that carries the nutrients and oxygen from the mother to the baby.

The LRRC8E subunit plays a critical role in the regulation of ion channels in various cell types. It is a voltage-regulated channel subunit, which means that it is regulated by changes in the voltage of the cell. When the voltage of the cell is increased, the LRRC8E subunit opens, allowing ions to flow through the channel and into or out of the cell. When the voltage of the cell is decreased, the LRRC8E subunit closed, preventing the flow of ions.

The LRRC8E subunit is involved in the regulation of a variety of different processes in the body. For example, it is involved in the regulation of muscle contractions, which are essential for movement. It is also involved in the regulation of the contraction and relaxation of blood vessels, which is important for maintaining blood pressure. The LRRC8E subunit is also involved in the regulation of the release of hormones from the pancreas, which is important for maintaining various bodily functions.

The LRRC8E subunit is a potential drug target, or biomarker, because of its involvement in the regulation of ion channels and various processes that are important for maintaining the health and function of the body. The development of compounds that can modulate the activity of the LRRC8E subunit could be useful for the treatment of a variety of conditions, including some neurological and cardiovascular disorders.

Conclusion

The LRRC8E subunit is a protein that is expressed in various tissues and cells throughout the human body. It is a key component of the voltage-regulated anion channel (VAC) family, which is involved in the regulation of ion channels in various cell types. The LRRC8E subunit is involved in the regulation of a variety of different processes in the body, including muscle contractions, blood vessel regulation, and the release of hormones.

The LRRC8E subunit is a potential drug target (or biomarker) due to its involvement in the regulation of ion channels and various processes that are important for maintaining the health and function of the body. The development of compounds that can modulate the activity of the LRRC8E subunit could be useful for the treatment of a variety of conditions, including some neurological and cardiovascular disorders. Further research is needed to fully understand the role of the LRRC8E subunit in the regulation of ion channels and the potential therapeutic uses of compounds that can modulate its activity.

Protein Name: Leucine Rich Repeat Containing 8 VRAC Subunit E

Functions: Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24790029, PubMed:26824658, PubMed:28193731). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (PubMed:24790029, PubMed:26824658). Mediates efflux of amino acids, such as aspartate, in response to osmotic stress (PubMed:28193731). The VRAC channel also mediates transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol (PubMed:33171122). Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:24790029, PubMed:26824658, PubMed:28193731). Also plays a role in lysosome homeostasis by forming functional lysosomal VRAC channels in response to low cytoplasmic ionic strength condition: lysosomal VRAC channels are necessary for the formation of large lysosome-derived vacuoles, which store and then expel excess water to maintain cytosolic water homeostasis (PubMed:33139539)

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