LRRC7: A protein of Potential Drug Target and Biomarker (G57554)

Target Name: LRRC7

NCBI ID: G57554

LRRC7

LRRC7: A protein of Potential Drug Target and Biomarker

The protein LRRC7 (Leucine-rich repeat-containing protein 7 isoform X1) is a highly conserved protein that is expressed in various cell types of the human body. It is characterized by a unique feature, a long terminal repeat (LRTC), which is a specific type of repetitive protein that is composed of a repeated sequence of amino acids. LRRC7 is expressed in various tissues, including brain, heart, skeletal muscles, and placenta, and has been implicated in various biological processes.

Drug Target Potential

The potential drug targets for LRRC7 are numerous and varied. One of the main targets of LRRC7 is its role in the regulation of cell signaling pathways, particularly in the signaling pathway known as the TGF-β pathway. TGF-β is a well-established signaling pathway that plays a crucial role in the development, maintenance, and regulation of tissues, including muscles, bones, and skin. LRRC7 has been shown to be involved in the regulation of TGF-β signaling by modulating the activity of the protein SMAD (small modal associative DNA-binding protein).

Additionally, LRRC7 has also been shown to be involved in the regulation of cell adhesion, a process that is critical for tissue repair and regeneration. LRRC7 has been shown to interact with the protein Focal Adhesion Protein (FAX), which is involved in cell adhesion, and modulates the activity of the protein PDGFR (Promyelocytic leukemia gene receptor) to promote the formation of new blood vessels.

Biomarker Potential

LRRC7 has also been shown to be involved in the regulation of cellular processes that are important for the diagnosis and prognosis of various diseases. For example, LRRC7 has been shown to be involved in the regulation of angiogenesis, a process that is critical for the formation of new blood vessels in response to tissue injury or disease. Additionally, LRRC7 has been shown to be involved in the regulation of cancer cell proliferation, a process that is critical for the development and progression of cancer.

Conclusion

In conclusion, LRRC7 is a protein that has the potential to be a drug target and biomarker. Its unique feature, the long terminal repeat, and various roles in cell signaling pathways, cell adhesion, and cancer cell proliferation make it an attractive target for drug development. Further research is needed to fully understand the functions of LRRC7 and its potential as a drug target and biomarker.

Protein Name: Leucine Rich Repeat Containing 7

Functions: Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long term depression

The "LRRC7 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about LRRC7 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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