INPP5A: A Potential Drug Target for Psychiatric Disorders (G3632)

Target Name: INPP5A

NCBI ID: G3632

INPP5A

INPP5A: A Potential Drug Target for Psychiatric Disorders

INPP5A (43 kDa inositol polyphosphate 5-phosphatase) is a protein that is expressed in various tissues throughout the body, including the brain, heart, and skeletal muscles. It is a key enzyme in the intracellular signaling pathway known as the Inositol Signaling cascade, which plays a crucial role in regulating various cellular processes, including cell survival, metabolism, and inflammation.

INPP5A is a small molecule that catalyzes the conversion of inositol monophosphate (IMP) to inositol polyphosphate (IP3). This reaction is a key step in the Inositol Signaling cascade, as the production of IP3 is the first step in the pathway. Once IP3 is produced, it can interact with various signaling molecules, including protein kinases, neurotransmitters, and ion channels. This interaction between IP3 and these molecules allows for the regulation of various cellular processes, including cell signaling, cell growth, and cell death.

INPP5A is a protein that has been identified as a potential drug target or biomarker for various neurological and psychiatric disorders. For example, INPP5A has been shown to be involved in the development and progression of Alzheimer's disease, a neurodegenerative disorder that is characterized by the accumulation of neurofibrillary tangles and beta-amyloid plaques in the brain. Studies have shown that increased levels of INPP5A and IP3 in the brain are associated with the development of Alzheimer's disease, and that inhibiting INPP5A activity may be a potential therapeutic approach.

INPP5A has also been shown to be involved in the development and progression of other psychiatric disorders, including depression and anxiety. For example, INPP5A has been shown to be involved in the regulation of the neurotransmitter serotonin, which is involved in mood regulation. Studies have shown that INPP5A activity is increased in the brains of individuals with depression, and that inhibiting INPP5A activity may be a potential therapeutic approach for treating this disorder.

In addition to its potential role in psychiatric disorders, INPP5A is also involved in the regulation of various physiological processes that are critical for human survival. For example, INPP5A is involved in the regulation of cell signaling, which is critical for the development and maintenance of tissues and organs. Studies have shown that INPP5A activity is increased in the hearts of individuals with heart disease, and that inhibiting INPP5A activity may be a potential therapeutic approach for treating heart disease.

Furthermore, INPP5A is also involved in the regulation of the immune system, which is critical for the defense against infection and disease. Studies have shown that INPP5A activity is increased in the immune cells of individuals with autoimmune disorders, and that inhibiting INPP5A activity may be a potential therapeutic approach for treating these disorders.

In conclusion, INPP5A is a protein that is involved in the regulation of various cellular processes that are critical for human survival. Its activity is regulated by various factors, including neurotransmitters, ion channels, and signaling molecules. INPP5A has been shown to be involved in the development and progression of various psychiatric and neurological disorders, including Alzheimer's disease, depression, anxiety, and heart disease. Therefore, INPP5A is a potential drug target or biomarker for these disorders, and its inhibition may be a promising therapeutic approach for the treatment of these conditions.

Protein Name: Inositol Polyphosphate-5-phosphatase A

Functions: Phosphatase that specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate, and inositol 1,3,4,5-tetrasphosphate to inositol 1,3,4-trisphosphate (PubMed:8013665, PubMed:8769125, PubMed:8626616). Plays a crucial role in the survival of cerebellar Purkinje cells (By similarity)

The "INPP5A Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about INPP5A comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets