INPP5D: A Potential Drug Target for Diabetes, Obesity and Neurodegenerative Disorders

Target Name: INPP5D

NCBI ID: G3635

INPP5D

Other Name(s): inositol polyphosphate-5-phosphatase D | Ssignaling inositol polyphosphate 5 phosphatase SIP-145 | Signaling inositol polyphosphate phosphatase SHIP II | SH2 domain-containing inositol 5'-phosphatase

INPP5D: A Potential Drug Target for Diabetes, Obesity and Neurodegenerative Disorders

INPP5D, also known as inositol polyphosphate-5-phosphatase D, is a protein that is expressed in various tissues throughout the body. It is a key enzyme in the intracellular signaling pathway known as the insulin/IGF-1 signaling pathway, which plays a crucial role in regulating various cellular processes in the body. INPP5D has been identified as a potential drug target and may also be a biomarker for several diseases, including diabetes, obesity, and neurodegenerative disorders.

The insulin/IGF-1 signaling pathway is a complex regulatory network that involves the interactions of multiple proteins. INPP5D is one of the key enzymes that links the intracellular signaling cascade to the production of inositol, a critical signaling molecule. Inositol is a simple sugar that is involved in various cellular processes, including the regulation of muscle contractions, the production of neurotransmitters, and the regulation of cell signaling.

INPP5D is a key enzyme in the production of inositol from the starting material, Glycogen. It catalyzes the transfer of a phosphate group from theG14伪 subunit to the alpha-phosphate group of the INPP5D protein. This transfer of a phosphate group is the final step in the production of inositol from Glycogen, and is critical for the initiation of the intracellular signaling pathway.

INPP5D has been shown to play a crucial role in the regulation of cellular processes that are important for various diseases, including diabetes, obesity, and neurodegenerative disorders. For example, INPP5D has been shown to be involved in the regulation of muscle contractions and the production of neurotransmitters, which are important for the diagnosis and treatment of neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease.

In addition to its role in the production of inositol, INPP5D has also been shown to play a critical role in the regulation of cellular signaling pathways. It has been shown to interact with various proteins, including the transcription factor, NF-kappa-B, and the protein, p53. These interactions play a crucial role in the regulation of cellular processes that are important for various diseases, including cancer and neurodegenerative disorders.

INPP5D has also been shown to be involved in the regulation of cellular metabolism and homeostasis. For example, it has been shown to play a role in the regulation of glucose metabolism, and to interact with the protein, GLUT1. This interaction between INPP5D and GLUT1 may play a role in the regulation of glucose levels and may be important for the diagnosis and treatment of diabetes.

In conclusion, INPP5D is a protein that is involved in the production of inositol and the regulation of various cellular processes that are important for the diagnosis and treatment of various diseases. Its role in the regulation of insulin/IGF-1 signaling pathway, muscle contractions, neurotransmitters, and cellular signaling pathways makes it a potential drug target and a biomarker for several diseases, including diabetes, obesity, and neurodegenerative disorders. Further research is needed to fully understand the role of INPP5D in the regulation of cellular processes and its potential as a drug target.

Protein Name: Inositol Polyphosphate-5-phosphatase D

Functions: Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways (PubMed:8723348, PubMed:10764818, PubMed:8769125). Able also to hydrolyzes the 5-phosphate of phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P3) and inositol 1,3,4,5-tetrakisphosphate (PubMed:9108392, PubMed:10764818, PubMed:8769125). Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity (PubMed:16682172). Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression

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•   expression level;
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