OR6J1: A GPCR Molecule in Human Sensory Function (G79549)

OR6J1: A GPCR Molecule in Human Sensory Function

Olfactory receptor, family 6, subfamily J, member 2 (OR6J1) is a protein that plays a crucial role in human sensory function. It is expressed in the sweat glands, hair follicles, and sebaceous glands, and its function is to detect the sensory stimuli that initiate the olfactory response. OR6J1 is a G protein-coupled receptor (GPCR), which means it uses a protein called G protein to transmit signals to other cells in the body.

OR6J1 is a member of the Olfactory Receptor gene family, which consists of over 300 genes that encode proteins involved in the sense of smell. The OR6J1 gene is located on chromosome 11.2 and encodes a 146 amino acid protein.

OR6J1 is a transmembrane protein, which means that it spans the cell membrane and is associated with the cytosol and the cell surface. It has a unique extracellular domain that is involved in its function. The N-terminus of OR6J1 contains a 尾-sheet, which is a structural domain that is common in GPCR proteins. This 尾-sheet is involved in the formation of a complex with the G protein.

The C-terminus of OR6J1 contains a unique structural domain that is called a catalytic loop. This loop is composed of a 尾-伪-helix and a 尾-尾-sheet. The catalytic loop is the site of the OR6J1's catalytic activity, which is involved in the conversion of a low-energy substrate to a higher-energy product.

OR6J1 is a GPCR that is involved in the sense of smell. It is one of the many olfactory receptors that are present in the human nose. When a sensory stimulus, such as a smell, enters the nose, it binds to the OR6J1 receptor. This causes a signaling cascade that activates various downstream signaling pathways, including the TGF-β pathway.

OR6J1 is a potential drug target because of its involvement in the sense of smell. Many drugs that are used to treat sensory disorders, such as Alzheimer's disease, diabetes, and cancer, have been shown to modulate the activity of OR6J1. For example, drugs that have been shown to increase the activity of OR6J1 include metformin, a drug used to treat diabetes, and cisapride, a drug used to treat ALS.

In addition to its potential as a drug target, OR6J1 is also a potential biomarker for certain diseases. For example, altered activity of OR6J1 has been observed in the brains of individuals with Alzheimer's disease, which suggests that it may be involved in the development and progression of this disease. Similarly, altered expression of OR6J1 has been observed in the nuclei of cancer cells, which may be a sign of their sensitivity to certain types of cancer treatments.

Overall, OR6J1 is a protein that plays a crucial role in human sensory function. Its unique structure and function make it an attractive target for drug development and research into the sense of smell. Further studies are needed to fully understand the role of OR6J1 in human sensory function and its potential as a drug target.

Protein Name: Olfactory Receptor Family 6 Subfamily J Member 1

Functions: Odorant receptor

The "OR6J1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about OR6J1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

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