OR6K2: A Role in The Olfactory System and Beyond (G81448)

OR6K2: A Role in The Olfactory System and Beyond

OR6K2 (Olfactory Receptor Family 6 Subfamily K Member 2) is a protein that is expressed in the olfactory epithelial cells of the nose and mouth. It plays a role in the sense of smell, and is also known as ENaC (Erythrosine N-Acetyltransferase).

OR6K2 is a member of the Olfactory Receptor Family 6, which is a large family of transmembrane proteins that include the olfactory receptors. These proteins are involved in the sense of smell and are responsible for sensing stimulation by gas molecules.

OR6K2 is a subfamily of the Olfactory Receptor Family 6, and is characterized by its extracellular domain, which consists of a single transmembrane alpha-helices region. This region contains a putative G protein-coupled receptor (GPCR) that is involved in the signaling pathway that transmits the sensory information from the olfactory epithelial cells to the brain.

Studies have shown that OR6K2 is involved in the development and maintenance of the olfactory system, and is thought to play a key role in the sense of smell. OR6K2 has been shown to interact with several other proteins, including the neurotransmitter glutamate (GABA) ), which is involved in the regulation of neural activity.

OR6K2 has also been shown to be involved in the regulation of the expression of other genes, including the gene encoding the olfactory receptor, known as OR6K1. This suggests that OR6K2 may be involved in the sense of smell by regulating the activity of the smell receptors.

In addition to its role in the sense of smell, OR6K2 has also been shown to be involved in the regulation of inflammation and cell survival. Studies have shown that OR6K2 is involved in the regulation of the production of pro-inflammatory cytokines, such as interleukin -8 (IL-8), which are involved in the inflammatory response.

OR6K2 has also been shown to be involved in the regulation of cell survival, by preventing the clearance of olfactory neurons by microtubules. This suggests that OR6K2 may be involved in the maintenance of the olfactory system by regulating the movement and survival of olfactory neurons.

Despite the potential role of OR6K2 in the sense of smell and other biological processes, more research is needed to fully understand its function. Studies are needed to determine the exact mechanism by which OR6K2 interacts with its downstream targets, such as glutamate and microtubules , and to determine its role in the regulation of the olfactory system and other biological processes.

In conclusion, OR6K2 is a protein that is expressed in the olfactory epithelial cells of the nose and mouth, and is involved in the sense of smell. It is a member of the Olfactory Receptor Family 6, and is characterized by its extracellular domain, which consists of a single transmembrane alpha-helices region. OR6K2 has been shown to interact with several other proteins, including the neurotransmitter glutamate, and is involved in the regulation of the expression of the olfactory receptor, as well as the regulation of inflammation and inflammation cell survival. Further research is needed to fully understand its function and role in the sense of smell.

Protein Name: Olfactory Receptor Family 6 Subfamily K Member 2

Functions: Odorant receptor

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More Common Targets

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