OR4K17: A Potential Drug Target and Biomarker for Fibrosis and Chronic Pain
OR4K17: A Potential Drug Target and Biomarker for Fibrosis and Chronic Pain
OR4K17, a member of the Olfactory Receptor Family 4 (ORF4), is a G protein-coupled receptor that plays a crucial role in sensory perception and pain signaling. OR4K17 is expressed in various tissues, including the central nervous system, peripheral tissues, and organs, and its function is highly conserved across species. Knockout of OR4K17 causes a variety of diseases, including neurodegeneration, pain, and fibrosis. Therefore, OR4K17 has become an attractive drug target and potential biomarker.
Discovery and drug development of OR4K17
The discovery of OR4K17 stems from research into neurodegenerative diseases and pain. As science and technology continue to advance, researchers' understanding of neurodegenerative diseases and pain is also increasing. Neurodegenerative diseases, such as Parkinson's disease, Alzheimer's disease, spinal muscular atrophy, etc., seriously affect patients' quality of life and health status. And pain, such as neuralgia, rheumatoid arthritis, cancer, etc., brings endless suffering to patients. Therefore, finding new drug targets has become an important means to treat these diseases.
OR4K17, as a G protein-coupled receptor, plays an important role in the nervous system. Studies have found that OR4K17 plays a key role in neuronal survival, proliferation, apoptosis and synapse formation. At the same time, OR4K17 is also closely related to the pain signal transmission of neurons. Knocking out OR4K17 causes neuronal damage, thereby exacerbating neurodegenerative diseases and pain.
Biomarker value of OR4K17
As a new biomarker, OR4K17 has broad application prospects in disease diagnosis, treatment and prognosis assessment. Here are some examples of OR4K17 as a biomarker:
1. The relationship between OR4K17 and neurodegenerative diseases
Neurodegenerative diseases, such as Parkinson's disease, Alzheimer's disease, and spinal muscular atrophy, often lead to neuronal damage and death. The knockout of OR4K17 can cause neuronal damage and aggravate these diseases. Therefore, OR4K17 can be used as a biomarker for these diseases to monitor disease development and treatment efficacy.
2. The relationship between OR4K17 and pain
Pain is an important physiological signal that plays an important role in maintaining the stability of the body's internal environment. However, when pain signals cannot be processed for a long time, it will cause neuronal damage and death, aggravating pain. Research has found that OR4K17 plays a key role in pain signaling in neurons. Therefore, OR4K17 can be used as a pain biomarker to evaluate the degree of pain and the effectiveness of treatment.
3. The relationship between OR4K17 and tumors
Tumor is a disease that seriously threatens human health. Research has found that OR4K17 plays an important role in tumor occurrence, growth and metastasis. Therefore, OR4K17 can be used as a tumor biomarker to monitor tumor development and treatment effects.
Therapeutic potential of OR4K17
OR4K17, as a new drug target, has significant therapeutic potential. First, OR4K17 has broad application prospects as a biomarker for neurodegenerative diseases, pain and tumors. Secondly, OR4K17 is expressed in multiple physiological systems such as the nervous system, endocrine system, and immune system, providing a broad space for drug research and development.
Drug development for OR4K17
OR4K17 drug research and development mainly focuses on the following aspects:
1. Drug Design
Drug design is a key link in OR4K17 drug development. Researchers used methods such as computer-aided drug design (CAD) and molecular simulation to speculate on highly conservative OR4K17 receptor antagonists. These antagonists can improve neuronal function, reduce pain and improve neurodegenerative diseases by regulating the signal transduction pathway of OR4K17 and affecting the expression of intracellular signaling molecules.
2. Drug Screening
Drug screening is an important part of OR4K17 drug development. Through in vitro and in vivo experiments, the researchers screened compounds with significant OR4K17 inhibitory activity for further screening. These compounds can serve as OR4K17 antagonists for the treatment of neurodegenerative diseases, pain and tumors.
3. Pharmacological effects
Pharmacological effects are an important part of OR4K17 drug development. Through in vivo and in vitro experiments, researchers can evaluate the affinity, efficacy, toxicity and other indicators of these compounds for the OR4K17 receptor, providing a basis for the clinical application of drugs. At the same time, these experiments can also reveal the mechanism of action of OR4K17 in physiological systems such as the nervous system, endocrine system, and immune system, and provide a theoretical basis for the pharmacological effects of drugs.
4. Clinical application
The clinical application of OR4K17 drugs mainly includes the following aspects:
(1) Neurodegenerative diseases
Neurodegenerative diseases such as Parkinson's disease,
Protein Name: Olfactory Receptor Family 4 Subfamily K Member 17
Functions: Odorant receptor
The "OR4K17 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about OR4K17 comprehensively, including but not limited to:
• general information;
• protein structure and compound binding;
• protein biological mechanisms;
• its importance;
• the target screening and validation;
• expression level;
• disease relevance;
• drug resistance;
• related combination drugs;
• pharmacochemistry experiments;
• related patent analysis;
• advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai
More Common Targets
OR4K2 | OR4K5 | OR4K6P | OR4K7P | OR4L1 | OR4M1 | OR4M2 | OR4M2-OT1 | OR4N2 | OR4N3P | OR4N4 | OR4N5 | OR4P4 | OR4Q3 | OR4S1 | OR4S2 | OR4T1P | OR4V1P | OR4X1 | OR4X2 | OR51A1P | OR51A2 | OR51A3P | OR51A4 | OR51A6P | OR51A7 | OR51B2 | OR51B4 | OR51B5 | OR51B6 | OR51C1P | OR51D1 | OR51E1 | OR51E2 | OR51F1 | OR51F2 | OR51G1 | OR51G2 | OR51H1 | OR51I1 | OR51I2 | OR51J1 | OR51L1 | OR51M1 | OR51Q1 | OR51S1 | OR51T1 | OR51V1 | OR52A1 | OR52A4P | OR52A5 | OR52B2 | OR52B4 | OR52B6 | OR52D1 | OR52E1 | OR52E2 | OR52E4 | OR52E5 | OR52E6 | OR52E8 | OR52H1 | OR52I1 | OR52I2 | OR52J3 | OR52K1 | OR52K2 | OR52K3P | OR52L1 | OR52M1 | OR52N1 | OR52N4 | OR52N5 | OR52R1 | OR52W1 | OR52Z1P | OR56A1 | OR56A3 | OR56A4 | OR56A5 | OR56B1 | OR56B4 | OR5A1 | OR5A2 | OR5AC1 | OR5AC2 | OR5AK2 | OR5AK4P | OR5AN1 | OR5AP2 | OR5AR1 | OR5AS1 | OR5AU1 | OR5B12 | OR5B17 | OR5B2 | OR5B21 | OR5B3 | OR5BA1P | OR5C1
