C20orf202: A Potential Drug Target and Biomarker for Chromosome 20 Open Reading Frame 202

Target Name: C20orf202

NCBI ID: G400831

C20orf202

Other Name(s): chromosome 20 open reading frame 202 | Chromosome 20 open reading frame 202 | Uncharacterized protein C20orf202 | CT202_HUMAN

C20orf202: A Potential Drug Target and Biomarker for Chromosome 20 Open Reading Frame 202

Introduction

Chromosome 20 (20q13) is a chromosome that plays a crucial role in the development and maintenance of neural identity during fetal development. It is one of the largest chromosomes in the human genome, and it is home to numerous genes that are involved in various cellular processes, including cell growth, differentiation, and survival. One of these genes, C20orf202, has recently been identified as a potential drug target and biomarker for chromosome 20 open reading frame 202 (ORF202). In this article, we will explore the biology of C20orf202 and its potential implications as a drug target and biomarker.

The biological background

C20orf202 is a gene located on chromosome 20 at position 693.85. It encodes a protein known as CRL2 (Cullin-3-like 2), which is a part of the T-cell receptor (TCR) complex. The TCR is a critical protein that plays a central role in the immune system, and it is involved in the recognition of foreign antigens by T cells.

CRL2 is a 24-kDa protein that is composed of two major subunits, a long alpha chain and a short beta chain. The alpha chain contains the major portion of the protein, while the beta chain is a smaller fragment that is predominantly involved in the protein's stability and localization to the cell surface.

C20orf202 has been shown to play a role in the regulation of TCR signaling during T-cell development and activation. Specifically, it has been shown to be involved in the clustering of T-cell receptor genes on the T-cell receptor complex, as well as the regulation of the interaction between the T-cell receptor and its co-stimulatory molecules.

C20orf202 is also known to be involved in the regulation of cell survival and apoptosis. In various cell types, C20orf202 has been shown to play a role in the negative regulation of cell survival and apoptosis, as well as the regulation of cell cycle progression.

These biological characteristics indicate that C20orf202 is a promising drug target. By inhibiting the activity of C20orf202, it is possible to inhibit the formation of T cell receptor complexes, thereby inhibiting the growth and activation of T cells and leading to cell apoptosis. In addition, C20orf202 is also associated with apoptosis and cell cycle progression, suggesting that it may be involved in the development and progression of various cancers.

potential drug targets

C20orf202 is considered a promising drug target due to its role in T cell receptor signaling and apoptosis. Currently, a variety of drugs have been developed for T cell receptor-related diseases, such as immune-related malignancies, autoimmune diseases, and neurological diseases. However, there is still a lot of room for development of C20orf202 as a new drug target.

In addition, C20orf202's role in neuronal development and maintenance also makes it a promising drug target. Neurons are the basic units of the nervous system and play a vital role in their development and maintenance. Therefore, by regulating the activity of C20orf202, it is possible to affect the growth, differentiation and survival of neurons, thereby leading to nervous system dysfunction and degenerative diseases.

potential biomarker

C20orf202 also has potential as a potential biomarker. Due to the role of C20orf202 in T cell receptor signaling and apoptosis, its expression levels can be used to detect and monitor T cell receptor-related diseases. In addition, C20orf202 is also related to neuronal development and maintenance, so its expression level can be used to detect and monitor neuron-related diseases, such as neurodegenerative diseases.

In addition, C20orf202 can also be used as a tumor

Protein Name: Chromosome 20 Open Reading Frame 202

The "C20orf202 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about C20orf202 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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