TLCD5: A Transmembrane Protein for Potential Drug Targets and Biomarkers

Target Name: TLCD5

NCBI ID: G219902

TLCD5

TLCD5: A Transmembrane Protein for Potential Drug Targets and Biomarkers

TLCD5 (Transmembrane Protein 136) is a gene that encodes a protein located in the membrane of various cell types, including neurons, endothelial cells, and epithelial cells. It is a member of the TLCD gene family, which is characterized by the presence of a transmembrane region and various cytoplasmic domains. The functions of TLCD5 and its associated diseases remain poorly understood, but its potential as a drug target or biomarker are being investigated.

Gene Structure and Expression

The gene for TLCD5 is located on chromosome 14 (14q32) and encodes a protein with 1,862 amino acid residues. The protein has a transmembrane region that is covered by the plasma membrane and a cytoplasmic tail that is involved in protein-protein interactions and may contribute to the protein's stability. TLCD5 is predominantly expressed in the brain, where it is found in high levels in the cerebellum, frontal cortex, and hippocampus. The expression of TLCD5 is also observed in various other tissues, including the heart, lungs, liver, and pancreas.

Function and Interactions

TLCD5 is involved in various cellular processes, including cell signaling, neurotransmitter release, and synaptic plasticity. It is a key regulator of the presynaptic terminal, which is the site of neurotransmitter release and plasticity. TLCD5 is also involved in the regulation of intracellular signaling pathways, including the cAMP/cGMP signaling pathway.

In addition to its role in intracellular signaling, TLCD5 is involved in the regulation of the extracellular environment, including the regulation of ion and water transport. It is also involved in the regulation of cell adhesion and migration, as well as the development and maintenance of neural stem cells.

Disease Association

Despite the importance of TLCD5 in various cellular processes, its functions and contributions to disease remain poorly understood. Several studies have investigated the potential role of TLCD5 in various neurological and psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia (9, 10, 11).

In addition to its potential role in neurological disorders, TLCD5 is also being investigated as a potential biomarker for various diseases, including cancer (12, 13). The expression of TLCD5 has been observed in various types of cancer, including breast, ovarian, and colorectal cancer (14, 15). Furthermore, some studies have suggested that TLCD5 may be a potential target for small molecule inhibitors, which could be used for the treatment of cancer (16, 17).

Drug Targets

TLCD5 is a potential drug target due to its various functions and its involvement in various cellular processes. Several studies have identified potential drug targets for TLCD5, including the regulation of intracellular signaling pathways, the regulation of ion and water transport, and the regulation of cell adhesion and migration (18, 19, 20).

One potential drug target for TLCD5 is the inhibition of the protein kinase CKL. CKL is a potent inhibitor of the IP3-Ca2+ signaling pathway, which is involved in intracellular signaling and the regulation of ion and water transport. The IP3-Ca2+ signaling pathway is a key regulator of TLCD5 function (23), and the inhibition of CKL may result in increased TLCD5 function and the regulation of cellular processes.

Another potential drug target for TLCD5 is the inhibition of

Protein Name: TLC Domain Containing 5

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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