Target Name: TJP3
NCBI ID: G27134
Review Report on TJP3 Target / Biomarker Content of Review Report on TJP3 Target / Biomarker
TJP3
Other Name(s): Tight junction protein ZO-3 | MGC119546 | Zona occludens protein 3 | Tight junction protein 3, transcript variant 1 | Zona occludens 3 | ZO-3 | zonula occludens protein 3 | zona occludens protein 3 | tight junction protein 3 (zona occludens 3) | tight junction protein 3 | ZO3_HUMAN | Zonula occludens protein 3 | Tight junction protein 3 | Tight junction protein 3 (zona occludens 3) | Tight junction protein ZO-3 (isoform 1) | TJP3 variant 1 | ZO3

TJP3: A Promising Drug Target and Biomarker for Tight Junction Protein ZO-3

Abstract:

Tight junction protein ZO-3 is an essential protein that plays a crucial role in maintaining tissue structure and various physiological processes. ZO-3 is often expressed in various tissues and has been implicated in various diseases, including cancer. The identification of potential drug targets and biomarkers for ZO-3 is crucial for the development of new therapeutic approaches. In this article, we discuss the potential of TJP3 as a drug target and biomarker for ZO-3.

Introduction:

Tight junction proteins (TJPs) are a family of transmembrane proteins that help to maintain tissue structure and physiological processes. ZO-3, also known as TJP3, is a member of the TJP family and has been extensively studied for its role in various physiological processes , including cell signaling, cell migration, and tissue development. ZO-3 is highly expressed in various tissues, including the skin, gut, and nervous system, and has been implicated in various diseases, including cancer.

The identification of potential drug targets and biomarkers for ZO-3 is crucial for the development of new therapeutic approaches. ZO-3 has been the focus of intense research due to its potential as a drug target. The identification of potential drug targets and biomarkers for ZO-3 can help to understand its underlying mechanisms and develop new therapeutic approaches for various diseases.

In this article, we discuss the potential of TJP3 as a drug target and biomarker for ZO-3. We will explore the structure and function of ZO-3 and its role in various physiological processes. We will also discuss the potential drug targets for ZO -3 and the development of new therapeutic approaches using ZO-3 as a biomarker.

Structure and Function of ZO-3:

ZO-3 is a 21-kDa transmembrane protein that consists of an N-terminus, a C-terminus, and an intermediate region. The N-terminus of ZO-3 contains a N-acetylated cysteine 鈥嬧?媟esidue, which is important for its stability and interactions with other proteins. The C-terminus of ZO-3 contains a cal hydrophobic Asp222 residue, which is known for its role in ZO-3's stability and interactions with other proteins.

The middle region of ZO-3 contains a unique sequence that is specific to ZO-3. This region contains a ZO-3 zinc finger and a ZO-3-specific domain. The ZO-3 zinc finger is a conserved protein that is involved in protein-protein interactions. The ZO-3-specific domain is unique to ZO-3 and is involved in ZO-3's stability and interactions with other proteins.

Function of ZO-3:

ZO-3 plays a crucial role in various physiological processes, including cell signaling, cell migration, and tissue development. ZO-3 is involved in the regulation of cell-cell adhesion, which is essential for the maintenance of tissue structure and the development of various tissues.

In addition to its role in cell-cell adhesion, ZO-3 is also involved in the regulation of cell signaling, including the regulation of mitochondrial function and the regulation of cellular signaling pathways. ZO-3 has been shown to interact with various transcription factors , including NF-kappa-B and AP-1, and has been involved in the regulation of various cellular processes, including cell proliferation, apoptosis, and inflammation.

Potential Drug Targets for ZO-3:

The identification of potential drug targets for ZO-3 is crucial for the development of new therapeutic approaches. ZO-3 has several potential drug

Protein Name: Tight Junction Protein 3

Functions: TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:16129888). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Binds and recruits PATJ to tight junctions where it connects and stabilizes apical and lateral components of tight junctions (PubMed:16129888). Promotes cell-cycle progression through the sequestration of cyclin D1 (CCND1) at tight junctions during mitosis which prevents CCND1 degradation during M-phase and enables S-phase transition (PubMed:21411630). With TJP1 and TJP2, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). Contrary to TJP2, TJP3 is dispensable for individual viability, embryonic development, epithelial differentiation, and the establishment of TJs, at least in the laboratory environment (By similarity)

The "TJP3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TJP3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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