Target Name: TJP1
NCBI ID: G7082
Review Report on TJP1 Target / Biomarker Content of Review Report on TJP1 Target / Biomarker
TJP1
Other Name(s): Tight junction protein ZO-1 (isoform b) | Tight junction protein 1, transcript variant 1 | TJP1 variant 1 | zonula occludens 1 protein | Zonula occludens protein 1 | Tight junction protein 1, transcript variant 3 | OTTHUMP00000174522 | Tight junction protein 1, transcript variant 2 | TJP1 variant 3 | Tight junction protein 1, transcript variant 5 | zona occludens 1 | ZO-1 | Tight junction protein 1 | Tight junction protein ZO-1 (isoform a) | MGC133289 | Tight junction protein ZO-1 (isoform e) | Tight junction protein ZO-1 | tight junction protein 1 | TJP1 variant 5 | ZO1 | ZO1_HUMAN | Zona occludens protein 1 | Zonula occludens 1 protein | OTTHUMP00000174520 | Tight junction protein ZO-1 isoform c | DKFZp686M05161 | Zona occludens 1 | TJP1 variant 2

TJP1: Potential Drug Target and Biomarker for Various Diseases

Tight junction protein ZO-1 (isoform b), also known as TJP1, is a protein that plays a crucial role in the formation and maintenance of tight junctions, which are specialized barriers that separate cells from their surroundings. In this article, we will discuss the potential drug target status of TJP1 and its potential as a biomarker for various diseases.

The tight junction is a specialized barrier that separates cells from their surroundings, such as the bloodstream and the surrounding tissue. This barrier is formed by a tight interplay of various proteins, including TJP1. TJP1 is a member of the tight junction protein family, which includes other proteins such as TJP2, TJP3, and TJP4. These proteins help to regulate the movement of cells and ensure that they remain separated from their surroundings.

One of the functions of TJP1 is to regulate the production of new tight junction proteins. This is important for maintaining the integrity of the tight junction barrier and for preventing cells from becoming too closely intertwined with each other. TJP1 has been shown to play a key role in this process by regulating the production of new TJP4 proteins.

Another function of TJP1 is its role in cell-cell adhesion. TJP1 helps to promote the stickiness of cells to their surrounding environment, which is important for the proper functioning of tissues and organs. This is important for the development and maintenance of tissues and organs, as well as for the regulation of various physiological processes.

In addition to its role in cell-cell adhesion and regulation of tight junction formation, TJP1 has also been shown to play a potential drug target role. The TJP1 gene has been implicated in various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. In addition, TJP1 has been shown to be a potential biomarker for several diseases, including cancer, neurodegenerative diseases, and autoimmune diseases.

One of the potential drug targets for TJP1 is its role in cancer. TJP1 has been shown to play a key role in the development and progression of various types of cancer, including breast, ovarian, and prostate cancer. TJP1 has also been shown to be involved in the regulation of cell division and the production of new cancer cells.

In addition to its role in cancer, TJP1 has also been shown to be involved in neurodegenerative diseases. TJP1 has been shown to play a key role in the regulation of the movement of cells and the formation of tight junctions in the brain. This is important for the proper functioning of the brain and for the development and maintenance of various neurological conditions.

Finally, TJP1 has also been shown to be involved in autoimmune diseases. TJP1 has been shown to play a key role in the regulation of the immune response and the production of antibodies. This is important for the proper functioning of the immune system and for the prevention of autoimmune diseases.

In conclusion, TJP1 is a protein that plays a crucial role in the formation and maintenance of tight junctions, which are specialized barriers that separate cells from their surroundings. TJP1 has been shown to play a key role in the regulation of new tight junction protein production, cell-cell adhesion, and the development and progression of various types of cancer. In addition, TJP1 has also been shown to be involved in neurodegenerative diseases and autoimmune diseases. As a result, TJP1 has the potential to be a drug target and a biomarker for various diseases.

Protein Name: Tight Junction Protein 1

Functions: TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity)

The "TJP1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TJP1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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TJP2 | TJP3 | TK1 | TK2 | TKFC | TKT | TKTL1 | TKTL2 | TLCD1 | TLCD2 | TLCD3A | TLCD3B | TLCD4 | TLCD4-RWDD3 | TLCD5 | TLDC2 | TLE1 | TLE1-DT | TLE2 | TLE3 | TLE4 | TLE5 | TLE6 | TLK1 | TLK2 | TLL1 | TLL2 | TLN1 | TLN2 | TLNRD1 | TLR1 | TLR10 | TLR12P | TLR2 | TLR3 | TLR4 | TLR5 | TLR6 | TLR7 | TLR8 | TLR8-AS1 | TLR9 | TLX1 | TLX1NB | TLX2 | TLX3 | TM2D1 | TM2D2 | TM2D3 | TM4SF1 | TM4SF1-AS1 | TM4SF18 | TM4SF19 | TM4SF19-AS1 | TM4SF19-DYNLT2B | TM4SF20 | TM4SF4 | TM4SF5 | TM6SF1 | TM6SF2 | TM7SF2 | TM7SF3 | TM9SF1 | TM9SF2 | TM9SF3 | TM9SF4 | TMA16 | TMA7 | TMBIM1 | TMBIM4 | TMBIM6 | TMC1 | TMC2 | TMC3 | TMC4 | TMC5 | TMC6 | TMC7 | TMC8 | TMCC1 | TMCC1-DT | TMCC2 | TMCC3 | TMCO1 | TMCO1-AS1 | TMCO2 | TMCO3 | TMCO4 | TMCO5A | TMCO5B | TMCO6 | TMED1 | TMED10 | TMED10P1 | TMED11P | TMED2 | TMED3 | TMED4 | TMED5 | TMED6