NFX1: A Protein Causing Cellular Processes and Potential Drug Targets

Target Name: NFX1

NCBI ID: G4799

NFX1

NFX1: A Protein Causing Cellular Processes and Potential Drug Targets

Nuclear transcription factor, X box-binding protein 1 (NFX1) is a protein that plays a crucial role in the regulation of gene expression. It is a key transcription factor that binds to the DNA-binding domain of various transcription factors, including nuclear factor of activating transcription (NFAT), which is a key transcription factor that regulates gene expression. NFX1 is a protein that has been identified as a potential drug target and a biomarker for various diseases, including cancer.

NFX1 was first identified in the early 1990s as a protein that interacts with the DNA-binding domain of NFAT. It is a 21-kDa protein that contains 4 zinc-finger transcription factor (TF) domains and a N-terminal alpha-helical structure domain. NFX1 is highly conserved across various species, and it has been shown to play a role in various cellular processes, including cell growth, differentiation, and transcriptional regulation.

One of the key functions of NFX1 is its ability to bind to the DNA-binding domain of NFAT. NFAT is a transcription factor that plays a crucial role in the regulation of gene expression by binding to specific DNA sequences. NFX1 is able to bind to the DNA-binding domain of NFAT and to NFAT-binding DNA, which allows it to regulate the activity of NFAT.

NFX1 is also involved in the regulation of gene expression by binding to other transcription factors. For example, NFX1 has been shown to bind to the DNA-binding domain of the RNA-binding protein (RBP) and to the domain of the transcription factor, TF-1. This allows NFX1 to regulate the activity of these transcription factors and to play a role in the regulation of gene expression.

In addition to its role in transcription regulation, NFX1 is also involved in the regulation of cellular processes such as cell growth, differentiation, and apoptosis. It is a transcription factor that has been shown to play a role in the regulation of cell growth by binding to the DNA-binding domain of the transcription factor, E2F1. Additionally, NFX1 is involved in the regulation of apoptosis, a process that is characterized by the programmed cell death of cells. It is a transcription factor that has been shown to play a role in the regulation of apoptosis by binding to the DNA-binding domain of the transcription factor, p53.

NFX1 is also a protein that has been identified as a potential drug target and a biomarker for various diseases, including cancer. For example, studies have shown that NFX1 is overexpressed in various types of cancer, including breast cancer and lung cancer. Additionally, NFX1 has been shown to be involved in the regulation of cancer cell migration and invasion, which are important processes that are involved in the development and progression of cancer.

In conclusion, NFX1 is a protein that plays a crucial role in the regulation of gene expression and is involved in various cellular processes. It is a potential drug target and a biomarker for various diseases, including cancer. Further research is needed to fully understand the role of NFX1 in cellular processes and its potential as a drug target.

Protein Name: Nuclear Transcription Factor, X-box Binding 1

Functions: Binds to the X-box motif of MHC class II genes and represses their expression. May play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Isoform 3 binds to the X-box motif of TERT promoter and represses its expression. Together with PABPC1 or PABPC4, isoform 1 acts as a coactivator for TERT expression. Mediates E2-dependent ubiquitination

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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