NGF: Potential Drug Target and Biomarker for Various Diseases

Target Name: NGF

NCBI ID: G4803

Content of Review Report on NGF Target / Biomarker

NGF

NGF: Potential Drug Target and Biomarker for Various Diseases

Pro-nerve growth factor long (NGF), also known as platelet-derived growth factor (PDGF), is a protein that plays a crucial role in cell growth and proliferation. It is a member of the tyrosine kinase family and is involved in various physiological processes, including tissue repair, wound healing, and development. NGF has been identified as a potential drug target and a biomarker for various diseases, including cancer, neurodegenerative diseases, and developmental disorders.

NGF is a transmembrane protein that is expressed in various tissues, including platelets, neurons, and epithelial cells. It has a critical role in cell signaling, specifically in the regulation of cell proliferation and survival. NGF signaling pathway has been studied extensively, and its various components have been identified.

One of the key components of the NGF signaling pathway is the NGF receptor, which is a protein that consists of an extracellular domain and an intracellular domain. The NGF receptor plays a crucial role in the regulation of cell proliferation and survival by interacting with the NGF protein.

NGF has been shown to promote cell growth, survival, and repair. It has been shown to stimulate the production of new platelets, which is important for wound healing and tissue repair. NGF has also been shown to promote the growth of various types of neurons , which is important for the development and maintenance of neural tissue. Additionally, NGF has been shown to play a role in the regulation of cell apoptosis, which is important for the maintenance of tissue homeostasis and the elimination of damaged or unnecessary cells.

NGF has also been shown to be involved in the regulation of cellular migration. It has been shown to promote the migration of various types of cells, including neurons and cancer cells, which is important for the development and progression of various diseases, including cancer.

NGF has also been shown to be involved in the regulation of angiogenesis, which is the process by which new blood vessels are formed. It has been shown to promote the formation of new blood vessels in various tissues, including the skin and the tumor.

NGF has also been shown to be involved in the regulation of cellular signaling pathways. It has been shown to interact with various signaling pathways, including the PI3K/Akt signaling pathway, which is involved in the regulation of cell survival and proliferation.

NGF has also been shown to be involved in the regulation of inflammation. It has been shown to promote the production of pro-inflammatory cytokines, which is important for the regulation of immune responses and the development of various inflammatory diseases.

NGF has also been shown to be involved in the regulation of tissue repair. It has been shown to promote the production of new cells during tissue repair, which is important for the regulation of wound healing and tissue regeneration.

NGF has also been shown to be involved in the regulation of cellular senescence. It has been shown to promote the production of senescent cells, which is important for the regulation of cellular aging and the development of various age-related diseases.

NGF has also been shown to be involved in the regulation of the Hedgehog signaling pathway. It has been shown to promote the formation of hair-like structures in various tissues, which is important for the regulation of growth and development.

NGF has also been shown to be involved in the regulation of theNotch signaling pathway. It has been shown to promote the formation of new tissues in various contexts, including the regulation of organ development and the development of cancer.

NGF has also been shown to be involved in the regulation of theFGF signaling pathway. It has been shown to promote the production of FGF, which is a growth factor for various types of cells, including neurons and cancer cells.

NGF has also been shown to be involved in the regulation of the PDGF signaling pathway. It has been shown to promote the production of PDGF, which is a growth factor for various types of cells, including neurons and cancer cells.

NGF has also been shown to be involved in the regulation of the TGF-β signaling pathway. It has been shown to promote the production of TGF-β, which is a growth factor for various types of cells, including muscles cells and fibroblasts.

NGF has also been shown to be involved in the regulation of the NF

Protein Name: Nerve Growth Factor

Functions: Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems (PubMed:14976160, PubMed:20978020). Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (PubMed:20978020) (Probable). The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse. In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro) (By similarity). Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI (PubMed:20164177). Binds lysophosphatidylinositol and lysophosphatidylserine between the two chains of the homodimer. The lipid-bound form promotes histamine relase from mast cells, contrary to the lipid-free form (By similarity)

The "NGF Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about NGF comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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