RDH11 Gene: Potential Drug Target for Age-related Macular Degeneration and Cataracts

Target Name: RDH11

NCBI ID: G51109

RDH11

RDH11 Gene: Potential Drug Target for Age-related Macular Degeneration and Cataracts

RDH11, also known as Retinol Dehydrogenase 11, is a gene that encodes a protein involved in the metabolism of retinol, a crucial nutrient for the retina. Retinol is a form of vitamin A that is essential for various functions in the retina, including visual perception and growth and development. The RDH11 gene has been associated with the development of certain diseases, including blindness and cataracts. As a result, it is a potential drug target and biomarker for a variety of diseases.

The RDH11 gene is a member of the superfamily of cytoskeletal proteins, which are involved in the structure and function of cells. The protein encoded by this gene is a member of the retinol dehydrogenase family, which is responsible for the metabolism of retinol to its active form. This protein is essential for the survival of the retina and plays a crucial role in the development and maintenance of vision.

The RDH11 gene has been associated with the development of various diseases, including age-related macular degeneration (AMD), which is a leading cause of blindness in the elderly. AMD is a progressive disease that is characterized by the gradual accumulation of waste material in the macula, a small area in the center of the retina that is responsible for our central vision. The accumulation of waste material in the macula can lead to a loss of vision and can ultimately result in blindness.

In addition to AMD, the RDH11 gene has also been associated with the development of cataracts, which is a condition in which the lens of the eye becomes cloudy and blocks light from reaching the retina. Cataracts can also lead to blindness.

The development of cataracts and AMD is thought to be caused by a combination of genetic and environmental factors. While the exact cause of these diseases is not yet fully understood, it is known that they are associated with the aging process and other risk factors, such as smoking, diabetes, and high blood pressure.

The RDH11 gene has also been linked to the development of other diseases, including some forms of cancer. This is because the protein encoded by this gene has been shown to be involved in the regulation of cell growth and division. In addition, the RDH11 gene has also been associated with the development of certain skin diseases, such as acne and rosacea.

In addition to its association with disease, the RDH11 gene has also been shown to have potential as a drug target. The RDH11 protein has been shown to be involved in the regulation of cell growth and division, which makes it a potential target for drugs that can be used to treat diseases associated with these processes, such as cancer and AMD. In addition, the RDH11 gene has also been shown to be involved in the metabolism of retinol, which makes it a potential target for drugs that can be used to treat conditions that are related to the metabolism of retinol, such as cataracts and macular degeneration.

In conclusion, the RDH11 gene is a protein that is involved in the metabolism of retinol, a crucial nutrient for the retina. The development of diseases associated with the aging process and other risk factors, such as smoking, diabetes, and high blood pressure, has led to the identification of the RDH11 gene as a potential drug target and biomarker. Further research is needed to understand the full role of the RDH11 gene in the development and progression of these diseases. However, the potential of this gene as a drug target and biomarker is an exciting area of research that has the potential to lead to new treatments for a variety of diseases.

Protein Name: Retinol Dehydrogenase 11

Functions: Retinol dehydrogenase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinol, and to a lesser extent on 13-cis-retinol (PubMed:12226107, PubMed:12036956, PubMed:29410696). Exhibits a low reductive activity towards unsaturated medium-chain aldehydes such as cis -6-nonenal and no activity toward nonanal or 4-hydroxy-nonenal (PubMed:15865448). Has no dehydrogenase activity towards steroid (PubMed:12226107, PubMed:12036956)

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