COX7A2L: A Potential Drug Target and Biomarker for Inflammatory Diseases

Target Name: COX7A2L

NCBI ID: G9167

COX7A2L

COX7A2L: A Potential Drug Target and Biomarker for Inflammatory Diseases

Introduction

The carboxyl oxidase (COX) is an important signal transduction molecule that plays a key role in a variety of physiological and pathological processes. COX7A2L (COX7R_HUMAN) is a humanized mouse carboxyl oxidase with high sequence conservation and similarity, and its encoding gene is COX7A2L. COX7A2L plays a key role in a variety of inflammatory responses and is therefore considered a potential drug target and biomarker. This article will elaborate on the mechanism of action, biological activity and current status of drug research of COX7A2L, and explore its clinical application prospects.

Mechanism of action of COX7A2L

COX7A2L is a trivalent carboxyl oxidase, including a chiral center (D-shaped ring structure), two achiral centers (S-shaped ring structure), and a sulfur-containing end group. The catalytic activity of COX7A2L relies on the sulfhydryl (-SH) functional group in the S-shaped ring structure. Under physiological conditions, the oxidation of sulfhydryl groups is masked by negative charges, so COX7A2L is less active in the extracellular environment. However, under pathological conditions such as inflammation and tissue damage, the oxidation of sulfhydryl groups is significantly enhanced, leading to the excessive accumulation of intracellular free radicals (reactive oxygen species, ROS).

The role of COX7A2L in inflammatory response

During the inflammatory response, COX7A2L functions in multiple cell types. First, COX7A2L plays an important role in macrophages (M桅). M桅 is the main inflammatory cell in the inflammatory response, and its activation requires the participation of COX7A2L. The binding of COX7A2L to inflammation-related proteins, such as tumor necrosis factor-alpha (TNF-alpha), interleukin-1 (IL-1), and interleukin-6 (IL-6), leads to the activation of these proteins and cellular Functional changes, thereby playing a key role in the inflammatory response.

Secondly, COX7A2L also plays an important role in neural tissue. Inflammatory neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease, are closely related to neuronal damage and apoptosis. Studies have shown that abnormal expression of COX7A2L in these diseases may be related to the pathogenesis of neuronal damage.

Biological activity of COX7A2L

COX7A2L has multiple biological activities, including antioxidant, anti-inflammatory and anti-cancer effects. First, COX7A2L has a strong antioxidant effect. Studies have found that COX7A2L can significantly reduce the content of intracellular free radicals and inhibit intracellular oxidative stress. Its mechanism of action may involve the oxidation of sulfhydryl groups and the activation of a series of antioxidant enzymes, such as superoxide dismutase (SOD) and glutathione peroxidase (GPx).

Secondly, COX7A2L has anti-inflammatory effects. Excessive activation of the inflammatory response may lead to excessive accumulation of intracellular free radicals, thereby causing a series of inflammatory injuries. COX7A2L reduces the degree of inflammatory damage by regulating the generation and clearance of intracellular free radicals. In addition, COX7A2L also has anti-cancer effects. Studies have shown that COX7A2L is expressed in a variety of tumor cells and can promote tumor growth. Therefore, COX7A2L may become a new anti-tumor drug target.

Current status of drug research on COX7A2L

At present, drug research on COX7A2L mainly focuses on inhibiting its activity, regulating its expression and anti-inflammatory effects.

1. Inhibit CO

Protein Name: Cytochrome C Oxidase Subunit 7A2 Like

Functions: Involved in the regulation of oxidative phosphorylation and energy metabolism (By similarity). Necessary for the assembly of mitochondrial respiratory supercomplex (By similarity)

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