COX4I1P1: A Potential Drug Target and Biomarker for Inflammation and Chronic Pain

Target Name: COX4I1P1

NCBI ID: G122867

COX4I1P1

Other Name(s): Cytochrome c oxidase subunit IV isoform 1 pseudogene 1 | COX4L1 | COX4P1 | cytochrome c oxidase subunit 4I1 pseudogene 1

COX4I1P1: A Potential Drug Target and Biomarker for Inflammation and Chronic Pain

Introduction

Cox4I1P1, also known as cytochrome c oxidase subunit IV isoform 1 pseudogene 1, is a gene that encodes a protein involved in the cytochrome c oxidase (CCO) system, which is a critical pathway in the regulation of cellular processes, including inflammation and pain. The CCO system is a large family of enzymes that participate in the production of reactive oxygen species (ROS), which can cause damage to tissues and contribute to the development of various diseases, including chronic pain and inflammatory disorders.

The discovery of COX4I1P1 as a potential drug target and biomarker for inflammation and chronic pain has significant implications for the development of new treatments for these conditions. While there are currently no FDA-approved drugs that specifically target COX4I1P1, research into its potential uses has shown promise in clinical trials.

Pathway to the CCO System

The CCO system is a complex network of enzymes that are involved in the production of ROS. The primary target of the CCO system is the cytochrome c oxidase (CCO), which is an enzyme that catalyzes the conversion of substrate oxygen to ROS. The CCO enzyme has four isoforms, each with a different chain of amino acids. COX4I1P1 is one of these isoforms, and it plays a crucial role in the regulation of cellular processes, including inflammation and pain.

The CCO system produces ROS through a series of electron transport chain (ETC) stages. The first step in the ETC is the production of a proton gradient by the redox state change of the noble factor. Then, the proton gradient drives the proton pump to transport protons from the cytosol to the corresponding ion pump on the cell membrane. These ion pumps include NADPH-dependent ATPase, Fo-ATP synthase and Mg-ATP synthase. These enzymes synthesize ATP driven by proton gradients in preparation for subsequent steps.

In the second step, the change in the redox state of the noble factor causes the proton gradient to disappear, and then the COX4I1P1 enzyme catalyzes the transport of protons from the corresponding ion pump on the cell membrane to the cytoplasm. This process involves the opening and closing of ion channels and the transport process of ion pumps. This process prepares you for subsequent steps.

In the third step, the proton gradient drives the transport of H+ ions from the corresponding ion pump on the cell membrane into the cytoplasm. This process involves H+ ion exchange H+ ion pumps, such as H+-ATPase and H+, K+-ATPase. These pumps transport H+ ions from the cytoplasm to the cell membrane in preparation for subsequent steps.

Finally, in the fourth step, H+ ions are excreted out of the cell through the corresponding ion pump on the cell membrane. This process involves H+ ion pumps, such as Mg2+-ATPase and Na+, K+-ATPase. These pumps excrete H+ ions from the cell membrane to the outside of the cell, thereby creating and disappearing the proton gradient.

The role of COX4I1P1

COX4I1P1 is a key component in the CCO system and has multiple biological functions in cells. First, COX4I1P1 is the precursor of ROS produced in cells. The production of intracellular ROS is mainly achieved through cytoplasmic transport and cell membrane transport. Secondly, COX4I1P1 can inhibit the production of intracellular ROS, thereby reducing the level of intracellular inflammatory response and oxidative stress.

COX4I1P1 is also involved in intracellular signal transduction processes. Within cells, a variety of signaling molecules such as hormones and extracellular signaling molecules bind to intracellular receptors, thereby triggering a series of cell biological reactions. COX4I1P1 can bind to a variety of signaling molecules in cells, such as leukotriene C1 and cyclooxygenase

Protein Name: Cytochrome C Oxidase Subunit 4I1 Pseudogene 1

The "COX4I1P1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about COX4I1P1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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