CPLANE1: A Transmembrane Protein as a Potential Drug Target and Biomarker

Target Name: CPLANE1

NCBI ID: G65250

CPLANE1

CPLANE1: A Transmembrane Protein as a Potential Drug Target and Biomarker

CPLANE1 (transmembrane protein ENSP00000382582) is a protein that has been identified as a potential drug target and biomarker. It is a member of the ENSP family, which is known for its involvement in various cellular processes, including intracellular signaling, response to stimuli, and cell survival. The ENSP family has been implicated in the development and progression of numerous diseases, including neurodegenerative disorders, cancer, and cardiovascular diseases. Therefore, the study of CPLANE1 and its potential drug targets is of great interest.

CPLANE1: Structure and Function

CPLANE1 is a 21-kDa transmembrane protein that is expressed in various tissues and cell types. It has a unique molecular structure, with a cytoplasmic tail and a transmembrane region that is characterized by a long extracellular domain and a short intracellular domain. The cytoplasmic tail of CPLANE1 is composed of a variable number of repeating amino acid residues, which is unique among proteins of its kind.

CPLANE1 functions as a negative regulator of the RhoA GTPase, which is a key regulator of cell signaling pathways. RhoA GTPase is involved in the regulation of many cellular processes, including cell growth, differentiation, and survival. The activity of RhoA GTPase is often associated with the development of cancer, neurodegenerative disorders, and cardiovascular diseases. Therefore, the study of CPLANE1 and its role in these processes is of great interest.

CPLANE1 as a Drug Target

CPLANE1 has been identified as a potential drug target due to its involvement in the regulation of RhoA GTPase. Many drugs that are currently in use target RhoA GTPase, with the goal of inhibiting its activity and reducing the risk of cancer, neurodegenerative disorders, and cardiovascular diseases. CPLANE1 is a good candidate for drug targeting because its activity in this pathway is well-established and its function is well-documented.

One of the challenges in targeting RhoA GTPase is its high stability, which allows it to resist inhibition by many drugs. However, CPLANE1 has several unique features that may make it more susceptible to targeted inhibition. First, its cytoplasmic tail is variable, which allows for the synthesis of different isoforms of CPLANE1 that may have different effects on RhoA GTPase activity. Second, CPLANE1 is a transmembrane protein, which means that its activity is primarily regulated by its extracellular environment. This may make it more responsive to inhibitors that target its intracellular signaling pathways.

CPLANE1 has been shown to play a role in the regulation of cellular processes that are important in cancer, neurodegenerative disorders, and cardiovascular diseases. For example, studies have shown that CPLANE1 is involved in the regulation of cell proliferation, migration, and survival. It has also been shown to play a role in the regulation of angiogenesis, which is the process by which new blood vessels are formed.

CPLANE1 has also been shown to be involved in the regulation of cellular signaling pathways that are important in neurodegenerative disorders. For example, studies have shown that CPLANE1 is involved in the regulation of neurotransmitter release from nerve axons, which is important in the development of neurodegenerative disorders. It has also been shown to play a role in the regulation of neuronal excitability, which is important in the development of neurodegenerative disorders.

CPLANE1 has also been shown to be involved in the regulation of cellular signaling pathways that are important in cardiovascular diseases. For example, studies have shown that CPLANE1 is involved in the regulation of angiogenesis,

Protein Name: Ciliogenesis And Planar Polarity Effector Complex Subunit 1

Functions: Involved in ciliogenesis (PubMed:25877302). Involved in the establishment of cell polarity required for directional cell migration. Proposed to act in association with the CPLANE (ciliogenesis and planar polarity effectors) complex. Involved in recruitment of peripheral IFT-A proteins to basal bodies (By similarity)

The "CPLANE1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CPLANE1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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