COX7A1: A Promising Drug Target and Biomarker for Pain Management
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COX7A1: A Promising Drug Target and Biomarker for Pain Management
Pain is an unpleasant sensation that affects millions of people worldwide. According to the World Health Organization (WHO), approximately 50% of the global population experiences chronic pain, with over 90% of those occurring in low- and middle-income countries. Efficient and effective pain management is critical for maintaining quality of life, and the global healthcare industry is dedicated to developing new treatments and approaches to manage pain. One promising drug target and biomarker for pain management is COX7A1, an enzyme involved in the synthesis of pro-inflammatory cytokines.
COX7A1 Overview
COX7A1, also known as COX-7, is a key enzyme in the cyclooxygenase (COX) family that is involved in the production of pro-inflammatory cytokines, such as prostaglandin E2 (PGE2) and etanerol (10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydroxy-10,12-epoxy-8,11-dihydro
Protein Name: Cytochrome C Oxidase Subunit 7A1
Functions: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
The "COX7A1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about COX7A1 comprehensively, including but not limited to:
• general information;
• protein structure and compound binding;
• protein biological mechanisms;
• its importance;
• the target screening and validation;
• expression level;
• disease relevance;
• drug resistance;
• related combination drugs;
• pharmacochemistry experiments;
• related patent analysis;
• advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai
More Common Targets
COX7A2 | COX7A2L | COX7A2P2 | COX7B | COX7B2 | COX7C | COX7CP1 | COX8A | COX8BP | COX8C | CP | CPA1 | CPA2 | CPA3 | CPA4 | CPA5 | CPA6 | CPAMD8 | CPB1 | CPB2 | CPB2-AS1 | CPD | CPE | CPEB1 | CPEB1-AS1 | CPEB2 | CPEB2-DT | CPEB3 | CPEB4 | CPED1 | CPHL1P | CPLANE1 | CPLANE2 | CPLX1 | CPLX2 | CPLX3 | CPLX4 | CPM | CPN1 | CPN2 | CPNE1 | CPNE2 | CPNE3 | CPNE4 | CPNE5 | CPNE6 | CPNE7 | CPNE8 | CPNE9 | CPOX | CPPED1 | CPQ | CPS1 | CPS1-IT1 | CPSF1 | CPSF1P1 | CPSF2 | CPSF3 | CPSF4 | CPSF4L | CPSF6 | CPSF7 | CPT1A | CPT1B | CPT1C | CPT2 | CPTP | CPVL | CPVL-AS2 | CPXCR1 | CPXM1 | CPXM2 | CPZ | CR1 | CR1L | CR2 | CRABP1 | CRABP2 | CRACD | CRACDL | CRACR2A | CRACR2B | CRADD | CRADD-AS1 | CRAMP1 | CRAT | CRAT37 | CRB1 | CRB2 | CRB3 | CRBN | CRCP | CRCT1 | Creatine Kinase | CREB1 | CREB3 | CREB3L1 | CREB3L2 | CREB3L3 | CREB3L4