CYRIB: A Key Regulator of Cytoskeletal Organization and Cell Function

Target Name: CYRIB

NCBI ID: G51571

CYRIB

CYRIB: A Key Regulator of Cytoskeletal Organization and Cell Function

CYRIB (CYFIP-related Rac1 interactor B) is a protein that is expressed in various tissues and cells throughout the body. It is a key regulator of the cytoskeleton and plays a crucial role in the development and maintenance of cell structure and function. CYRIB is also known as RAC1 (relative to the centromere), and its function is to interact with the protein called Rac1.

The cytoskeleton is a complex network of filaments and organizing structures that provide structural support for cells, as well as involved in their mechanical properties and movement. The cytoskeleton is composed of a variety of proteins, including microtubules, actin filaments, and intermediate filaments. These proteins are held together by a complex of interactions, including those between the cytoskeleton and the associated proteins.

One of the key proteins that interact with the cytoskeleton is Rac1. Rac1 is a small G protein that is involved in the regulation of cell growth, differentiation, and cytoskeletal organization. It is composed of four subunits, A, B, C, and D , that are held together by a disulfide bond.

CYRIB is a protein that is highly expressed in various tissues and cells, including muscle, heart, brain, and blood vessels. It is also highly expressed in the developing nervous system, and its expression is regulated by a variety of factors, including growth factors , Wnt signaling, and cell cycle progression.

One of the functions of CYRIB is to regulate the activity of Rac1. This is done through a process called interaction between CYRIB and Rac1. This interaction between the two proteins is critical for the regulation of Rac1 activity and the cytoskeleton organization.

In addition to regulating Rac1 activity, CYRIB is also involved in the regulation of the actin cytoskeleton. This is done through a process called interaction between CYRIB and the protein F-actin. This interaction between the two proteins is critical for the regulation of actin organization and cytoskeletal stability.

CYRIB is also involved in the regulation of the distribution of proteins in the cytoskeleton. This is done through a process called interaction between CYRIB and the protein N-cadherin. This interaction between the two proteins is critical for the regulation of protein distribution and cytoskeletal organization.

CYRIB is a protein that is highly expressed in various tissues and cells, and it plays a critical role in the regulation of cytoskeletal organization and the development and maintenance of cell structure and function. Its interaction with Rac1 is a key regulator of this process, and Its function is to regulate the activity of Rac1 and the actin cytoskeleton, as well as the distribution of proteins in the cytoskeleton.

It is interesting to note that CYRIB is also known as RAC1 (relative to the centromere), and it is part of the RAC1/RhoA complex. This complex plays a role in regulating the cytoskeleton organization and the development of the nervous system.

In conclusion, CYRIB is a protein that is highly expressed in various tissues and cells, and it plays a critical role in the regulation of cytoskeletal organization and the development and maintenance of cell structure and function. Its interaction with Rac1 is a key regulator of this process, and its function is to regulate the activity of Rac1 and the actin cytoskeleton, as well as the distribution of proteins in the cytoskeleton. Its role in the regulation of cytoskeleton organization and the development of the nervous system makes CYRIB an attractive drug target and a potential biomarker.

Protein Name: CYFIP Related Rac1 Interactor B

Functions: Negatively regulates RAC1 signaling and RAC1-driven cytoskeletal remodeling (PubMed:31285585, PubMed:30250061). Regulates chemotaxis, cell migration and epithelial polarization by controlling the polarity, plasticity, duration and extent of protrusions. Limits Rac1 mediated activation of the Scar/WAVE complex, focuses protrusion signals and regulates pseudopod complexity by inhibiting Scar/WAVE-induced actin polymerization (PubMed:30250061). Protects against Salmonella bacterial infection. Attenuates processes such as macropinocytosis, phagocytosis and cell migration and restrict sopE-mediated bacterial entry (PubMed:31285585). Restricts also infection mediated by Mycobacterium tuberculosis and Listeria monocytogenes (By similarity). Involved in the regulation of mitochondrial dynamics and oxidative stress (PubMed:29059164)

The "CYRIB Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CYRIB comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets