STK26: A Potential Drug Target and Biomarker for MST3 and SOK1-Related Kinases

Target Name: STK26

NCBI ID: G51765

STK26

STK26: A Potential Drug Target and Biomarker for MST3 and SOK1-Related Kinases

Stimulated by metabolic stress, protein kinases (PKs) are involved in regulating various cellular processes to maintain homeostasis. The serine/threonine protein kinase STK26 is one of the kinases that play a crucial role in the regulation of cellular stress responses. STK26 is a member of the STK2 family, which includes several related kinases, including MST3 and SOK1-related kinases. In this article, we will discuss STK26 as a potential drug target and biomarker for MST3 and SOK1-related kinases.

STK26: A Critical Kinase for Cellular Stress Response

STK26 is a 21-kDa protein that is expressed in various cell types, including neurons, macrophages, and cancer cells.1 STK26 is involved in the regulation of several cellular processes, including cell signaling, cell division, apoptosis, and DNA damage repair.2 STK26 is a key regulator of the DNA damage repair pathway, which is critical for the survival of cells exposed to DNA-proximals, such as those generated by mutational or cellular stress events.3

In addition to its role in the DNA damage repair pathway, STK26 is involved in the regulation of cell signaling pathways that are critical for cellular stress responses.4 For example, STK26 is involved in the regulation of the PI3K/AKT signaling pathway, which is involved in the regulation of cellular metabolism and growth.5

MST3 and SOK1-Related Kinases: Functions and Interactions

MST3 (Mstn1) and SOK1-related kinases are both serine/threonine protein kinases that are involved in the regulation of cellular stress responses.6 MST3 is a potent inhibitor of the DNA damage repair pathway,7 while SOK1-related kinases are involved in the regulation of cell signaling pathways, including cell division and apoptosis.8

MST3 and SOK1-related kinases have several interacting functions. For example, MST3 can inhibit the activity of SOK1-related kinases, including SOK1 and SOK3,9 which may limit their ability to promote cell proliferation and survival.10 Additionally, MST3 can interact with SOK1-related kinases to regulate their activity in the regulation of cell signaling pathways.11

STK26 as a Potential Drug Target

The inhibition of STK26 activity by small molecules has the potential to be a useful therapeutic approach for the treatment of various diseases.12 STK26 has been identified as a potential drug target for the treatment of various diseases, including cancer,13 neurodegenerative diseases,14 and autoimmune diseases.15

In addition to its potential therapeutic applications, STK26 has also been identified as a potential biomarker for several diseases.16 The inhibition of STK26 activity has been shown to be associated with the development of various diseases, including cancer,17 neurodegenerative diseases,18 and autoimmune diseases.19

Conclusion

In conclusion, STK26 is a critical kinase involved in the regulation of cellular stress responses. Its inhibition has the potential to be a useful therapeutic approach for the treatment of various diseases. Additionally, STK26 has also been identified as a potential biomarker for several diseases, which may have implications for the development of diagnostic tests and biomarkers for these diseases. Further research is needed to fully understand the role of STK26 in cellular stress responses and its potential as a drug target and biomarker.

Protein Name: Serine/threonine Kinase 26

Functions: Serine/threonine-protein kinase that acts as a mediator of cell growth (PubMed:11641781, PubMed:17360971). Modulates apoptosis (PubMed:11641781, PubMed:17360971). In association with STK24 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation (PubMed:27807006). Phosphorylates ATG4B at 'Ser-383', thereby increasing autophagic flux (PubMed:29232556)

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