ATP8B1: Phospholipid Transport and ATPase Activity (G5205)

Target Name: ATP8B1

NCBI ID: G5205

ATP8B1

ATP8B1: Phospholipid Transport and ATPase Activity

ATPase phospholipid transporting 8B1 (ATP8B1) is a protein that plays a critical role in the transfer of phospholipid across cell membranes. It is a member of the ATPase family, which is a well-known group of proteins that transfer ATP energy across cell membranes to maintain the integrity of the cell's membrane. The ATPase family is composed of several subfamilies, including the B1 subfamily, which includes ATPase phospholipid transporting 8B1 (ATP8B1) as its best-known member.

ATP8B1 is a 21-kDa protein that is expressed in most tissues and cells of higher animals. It is primarily localized to the endoplasmic reticulum (ER), which is the primary site of protein synthesis and quality control in the cell. The ER is a dynamic organelle that is involved in the synthesis, folding, and storage of proteins. It is also the site of ATPase activity, which is the transfer of ATP energy across cell membranes.

ATP8B1 is a member of the ATPase family B1, which includes several other proteins that share similar localization and function. These proteins include ATPase B1 (ATP8B2), ATPase B2 (ATP8B3), and ATPase B3 (ATP8B4). All of these proteins are involved in the transfer of ATP energy across cell membranes, and they share a conserved catalytic core that includes a catalytic active site and a nucleotide-binding site.

The function of ATP8B1 is to participate in the transfer of ATP energy across the cell membrane to maintain the integrity of the cell's membrane. It does this by using the energy from ATP to pump protons across the membrane. Protons are important for maintaining the stability of the cell's membrane, and they play a central role in many cellular processes, including the regulation of ion channels, the transport of nutrients and waste products, and the signaling of intracellular events.

ATP8B1 is involved in the transfer of ATP energy across the cell membrane by using the energy from ATP to pump protons across the membrane. This process is known as ATP-dependent transmembrane transport, and it is a critical mechanism for maintaining the integrity of the cell's membrane.

ATP8B1 is a protein that is being targeted by researchers as a potential drug target or biomarker. Several studies have identified potential drug-conjugated antibodies or peptides that can interact with ATP8B1 and enhance its expression. These antibodies or peptides have been shown to enhance the localization of ATP8B1 to the endoplasmic reticulum, which is the primary site of protein synthesis and quality control in the cell.

In addition to its potential as a drug target, ATP8B1 is also a potential biomarker for certain diseases. The loss of ATPase activity has been observed in a variety of diseases, including neurodegenerative disorders, cardiomyopathies, and diseases that affect the endoplasmic reticulum. Therefore, Research shows that ATP8B1 can serve as a therapeutic target or biomarker for certain diseases.

Overall, ATP8B1 is a very important protein that plays a key role in transferring ATP energy across the cell membrane to maintain the integrity of the cell membrane and many other biological processes. Its function is to pump protons from one membrane to another by using the energy of ATP, which is one of the key mechanisms in maintaining the integrity of cell membranes. In addition, ATP8B1 is a target and researchers are studying how to use drugs or other methods to interfere with its function and use it as a promising drug target or biomarker.

Protein Name: ATPase Phospholipid Transporting 8B1

Functions: Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of phospholipids, in particular phosphatidylcholines (PC), from the outer to the inner leaflet of the plasma membrane (PubMed:25315773, PubMed:17948906). May participate in the establishment of the canalicular membrane integrity by ensuring asymmetric distribution of phospholipids in the canicular membrane (By similarity). Thus may have a role in the regulation of bile acids transport into the canaliculus, uptake of bile acids from intestinal contents into intestinal mucosa or both and protect hepatocytes from bile salts (By similarity). Involved in the microvillus formation in polarized epithelial cells; the function seems to be independent from its flippase activity (PubMed:20512993). Participates in correct apical membrane localization of CDC42, CFTR and SLC10A2 (PubMed:25239307, PubMed:27301931). Enables CDC42 clustering at the apical membrane during enterocyte polarization through the interaction between CDC42 polybasic region and negatively charged membrane lipids provided by ATP8B1 (By similarity). Together with TMEM30A is involved in uptake of the synthetic drug alkylphospholipid perifosine (PubMed:20510206). Required for the preservation of cochlear hair cells in the inner ear (By similarity). May act as cardiolipin transporter during inflammatory injury (By similarity)

The "ATP8B1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ATP8B1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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