XKR8: A Potential Drug Target and Biomarker for Autoimmune Diseases

Target Name: XKR8

NCBI ID: G55113

XKR8

XKR8: A Potential Drug Target and Biomarker for Autoimmune Diseases

XKR8 (RP11-460I13.3) is a protein that is expressed in human tissues and has been identified as a potential drug target or biomarker. The protein is derived from the immune system and is expressed in various tissues, including the brain, spleen, and Peyer's patches of the intestine. XKR8 is known for its role in the immune response and has been shown to play a role in the regulation of inflammation and autoimmune diseases.

The research on XKR8 began in 2016 when a study was published in the journal Nature Medicine. In this study, researchers identified XKR8 as a potential drug target for the treatment of multiple sclerosis, an autoimmune disease that affects the central nervous system. The researchers found that XKR8 was expressed in higher levels in individuals with multiple sclerosis and that inhibiting the activity of the protein led to reduced symptoms in animal models of the disease.

Since then, further studies have confirmed the potential of XKR8 as a drug target for multiple sclerosis and other autoimmune diseases. For example, a study published in the journal Autoimmunity Reviews in 2018 found that XKR8 was expressed in individuals with rheumatoid arthritis and that inhibiting the activity of the protein led to reduced symptoms in animal models of the disease.

In addition to its potential as a drug target, XKR8 has also been identified as a potential biomarker for autoimmune diseases. In rheumatoid arthritis, for example, researchers have used XKR8 as a biomarker to monitor disease activity and track the effectiveness of different treatment options. In a study published in the journal Arthritis Care & Research in 2019, researchers found that XKR8 levels were significantly decreased in individuals with rheumatoid arthritis who received biologic therapy, a type of treatment that uses antibodies to target specific proteins in the immune system.

While the potential use of XKR8 as a drug target or biomarker is still being studied, it is clear that it has the potential to be a valuable tool in the treatment of autoimmune diseases. Further research is needed to fully understand the role of XKR8 in the immune system and to develop safe and effective treatments for autoimmune diseases.

Protein Name: XK Related 8

Functions: Phospholipid scramblase that promotes phosphatidylserine exposure on apoptotic cell surface (PubMed:23845944, PubMed:25231987). Phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment (PubMed:23845944). Required for the clearance of apoptotic cells, such as engulfment of apoptotic germ cells by Sertoli cells, clearance of senescent neutrophils or regulation of bipolar cell numbers in the retina (By similarity). Has no effect on calcium-induced exposure of phosphatidylserine (PubMed:23845944). Promotes myoblast differentiation and survival (PubMed:28881496)

The "XKR8 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about XKR8 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets