XNDC1N: A Potential Drug Target and Biomarker (G100133315)

Target Name: XNDC1N

NCBI ID: G100133315

XNDC1N

Other Name(s): LOC100133315 | putative short transient receptor potential channel 2-like protein | Transient receptor potential cation channel, subfamily C, member 2-like | XRCC1 N-terminal domain containing 1, N-terminal like | XRCC1 N-terminal domain containing 1-like protein | trpC2-like protein

XNDC1N: A Potential Drug Target and Biomarker

XNDC1N is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. Its function is not well understood, but it is known to play a role in the regulation of blood pressure, proteinuria, and glomerulosclerosis. As a result, it has been identified as a potential drug target and biomarker for various diseases, including hypertension, diabetes, and chronic kidney disease.

The Druggability of XNDC1N

XNDC1N is a member of the superfamily of C-type nucleotide-binding proteins (NBP), which are a subclass of transmembrane proteins that regulate various cellular processes, including DNA replication, gene expression, and signaling pathways. NBP proteins have been shown to play a critical role in the regulation of stem cell self-renewal and differentiation, as well as in the regulation of inflammation and fibrosis.

One of the key features of XNDC1N is its ability to interact with various transcription factors, including nuclear factor-kappa-B (NF-kappa-B), transforming growth factor-尾1 (TGF-β1), and NF-E2. These transcription factors are involved in the regulation of various cellular processes, including inflammation, angiogenesis, and fibrosis. As a result, XNDC1N has been shown to play a role in the regulation of these processes, which may make it a potential drug target for diseases that are characterized by inflammation or fibrosis.

The Potential Biomarkers of XNDC1N

In addition to its potential as a drug target, XNDC1N has also been identified as a potential biomarker for several diseases. For example, it has been shown to be highly expressed in the urine of patients with diabetic nephropathy, a common complication of diabetes that can lead to kidney failure. Additionally, it has been shown to be highly expressed in the blood of patients with heart failure, a condition that is characterized by the inability of the heart to pump enough blood to meet the body's needs.

XNDC1N has also been shown to be expressed in the urine and plasma of patients with hypertension, a condition that is characterized by an increase in blood pressure. Additionally, it has been shown to be expressed in the blood of patients with chronic kidney disease, a condition that is characterized by the loss of kidney function over time.

The Future of XNDC1N as a Drug Target

The identification of XNDC1N as a potential drug target and biomarker has significant implications for the development of new treatments for a variety of diseases. For example, XNDC1N has been shown to play a role in the regulation of inflammation and fibrosis, which may make it a potential target for diseases characterized by these processes, such as rheumatoid arthritis, fibrositis, and cancer.

In addition to its potential as a drug target, XNDC1N has also been shown to be a potential biomarker for several diseases, including diabetes, heart failure, and chronic kidney disease. The identification of these potential biomarkers has significant implications for the development of new diagnostic tests and therapies for these diseases.

Conclusion

XNDC1N is a protein that has been identified as a potential drug target and biomarker for several diseases. Its function is not well understood, but it is known to play a role in the regulation of blood pressure, proteinuria, and glomerulosclerosis. The identification of XNDC1N as a potential drug target and biomarker has significant implications for the development of new treatments for a variety of diseases. Further research is needed to fully understand its function and potential as a drug target and biomarker.

Protein Name: XRCC1 N-terminal Domain Containing 1, N-terminal Like

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