PRR5: Potential Drug Target Or Biomarker for Various Diseases

Target Name: PRR5

NCBI ID: G55615

PRR5

PRR5: Potential Drug Target Or Biomarker for Various Diseases

PRR5, also known as Proline-rich 5 (Renal), is a protein that is expressed in the kidney and has been shown to play a role in various physiological processes in the kidney, including regulation of water and electrolyte balance, and immune surveillance. The protein is made up of 51 amino acids, with the last 10 amino acids being rich in proline residues.

Recent studies have suggested that PRR5 may have potential as a drug target or biomarker for various diseases, including diabetes, hypertension, and chronic kidney disease. This is because the protein has been shown to interact with a variety of molecules, including transcription factors, signaling proteins, and ions. Additionally, the protein has been shown to play a role in regulating various cellular processes, including cell growth, apoptosis, and inflammation.

One potential mechanism by which PRR5 may be involved in diabetes is its role in insulin sensitivity. Studies have shown that PRR5 can interact with the transcription factor, PDX1, to regulate insulin sensitivity in cancer cells. This suggests that PRR5 may be a potential target for drugs that improve insulin sensitivity in diabetes.

Another potential mechanism by which PRR5 may be involved in hypertension is its role in regulating sodium and water balance. Studies have shown that PRR5 can interact with the ion channel, TRPV6, to regulate sodium and water intake in the kidney. This suggests that PRR5 may be a potential target for drugs that can improve sodium and water balance in hypertension.

PRR5 has also been shown to play a role in immune surveillance in the kidney. Studies have shown that PRR5 can interact with the transcription factor, NF-kappa-B, to regulate immune cell function in the kidney. This suggests that PRR5 may be a potential target for drugs that can improve immune surveillance in the kidney.

In addition to its potential as a drug target or biomarker, PRR5 has also been shown to have potential as a diagnostic tool. Studies have shown that PRR5 can be expressed in the urine and plasma, making it a potential biomarker for kidney disease. Additionally, the protein has been shown to be expressed in various types of cancer, including colon cancer, which suggests that it may be a potential biomarker for cancer as well.

Overall, PRR5 is a protein that has been shown to play a role in various physiological processes in the kidney, including regulation of water and electrolyte balance, and immune surveillance. Its potential as a drug target or biomarker for various diseases makes it an attractive target for further research.

Protein Name: Proline Rich 5

Functions: Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling. May act as a tumor suppressor in breast cancer

The "PRR5 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PRR5 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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