PRMT8: The Protein Arginine Methyltransferase 8 (G56341)

Target Name: PRMT8

NCBI ID: G56341

PRMT8

PRMT8: The Protein Arginine Methyltransferase 8

PRMT8 (Protein Arginine Methyltransferase 8) is a enzyme involved in the process of protein arginine methylation, which plays a crucial role in the regulation of various cellular processes, including cell growth, differentiation, and inflammation. The identification of PRMT8 as a potential drug target or biomarker has significant implications for the development of new therapeutic strategies for various diseases.

Background

Protein arginine methylation is a post-translational modification (PTM) that involves the addition of an arginine molecule to specific amino acid residues. This modification plays a vital role in the regulation of various cellular processes, including cell growth, differentiation, and inflammation. PRMT8 is a key enzyme involved in the formation of this PTM.

PRMT8 functions as a critical enzyme in the regulation of cell growth and differentiation. It is involved in the regulation of cell proliferation, apoptosis, and angiogenesis, which are essential processes for the development and maintenance of tissues and organs. PRMT8 has been shown to play a crucial role in the regulation of cell cycle progression, where it helps to control the entry of new arginine residues into the protein.

PRMT8 is also involved in the regulation of cellular differentiation and cell-cell adhesion. It has been shown to be involved in the regulation of stem cell proliferation and the development of tissues and organs, including neural cells and cancer cells.

In addition to its role in cell growth and differentiation, PRMT8 is also involved in the regulation of inflammation. It has been shown to play a crucial role in the regulation of immune cell function and the production of inflammatory cytokines.

Drug Targeting and Biomarker

The identification of PRMT8 as a potential drug target or biomarker has significant implications for the development of new therapeutic strategies for various diseases. PRMT8 has been shown to be involved in the regulation of various cellular processes, including cell growth, differentiation, and inflammation. Therefore, targeting PRMT8 with drugs or other therapeutic agents may be an effective way to treat various diseases.

One potential approach to targeting PRMT8 is through the inhibition of its activity. This can be achieved through the use of small molecules, such as inhibitors, or through the use of antibodies that specifically target PRMT8. These approaches have been shown to be effective in animal models of various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases.

Another approach to targeting PRMT8 is through the use of biomarkers. PRMT8 is a protein that can be easily isolated from cell culture supernatants, making it an attractive biomarker for various diseases. The use of PRMT8 as a biomarker may be an effective way to diagnose and monitor the progression of diseases, as well as to assess the effectiveness of therapeutic interventions.

Conclusion

PRMT8 is a protein involved in the regulation of various cellular processes, including cell growth, differentiation, and inflammation. Its inhibition or inhibition-based biomarker has significant implications for the development of new therapeutic strategies for various diseases. Further research is needed to fully understand the role of PRMT8 in the regulation of cellular processes and its potential as a drug target or biomarker.

Protein Name: Protein Arginine Methyltransferase 8

Functions: S-adenosyl-L-methionine-dependent and membrane-associated arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA) in proteins such as NIFK, myelin basic protein, histone H4, H2A and H2A/H2B dimer (PubMed:16051612, PubMed:17925405, PubMed:26876602, PubMed:26529540). Able to mono- and dimethylate EWS protein; however its precise role toward EWS remains unclear as it still interacts with fully methylated EWS (PubMed:18320585)

The "PRMT8 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PRMT8 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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