DHX37: A Potential Drug Target and Biomarker (G57647)

Target Name: DHX37

NCBI ID: G57647

DHX37

DHX37: A Potential Drug Target and Biomarker

Introduction

Dihu DHX37 (Probable ATP-dependent RNA helicase DHX37) is a protein that plays a crucial role in various cellular processes. It is a member of the DHX family that is known to regulate gene expression and contribute to the regulation of DNA replication, transcription, and post-transcriptional modification. DHX37 is highly conserved across various species, and it has been identified as a potential drug target and biomarker [2,3].

Purpose of the Article

The primary objective of this article is to provide an overview of DHX37, including its structure, function, and potential as a drug target and biomarker. This article will focus on the molecular mechanisms underlying DHX37's function as a potential drug target and the potential clinical applications of targeting DHX37.

Structure and Function

Dihu DHX37 is a 21 kDa protein that contains 109 amino acid residues. It has a characteristic Rossmann-fold structure that is characteristic of proteins that function as RNA helicases. DHX37 has been shown to play a role in the regulation of gene expression by modifying the RNA secondary structure.

DHX37 functions as an RNA helicase by promoting the recruitment of RNA factors to its active site, which is located at the base pairing between the 5' end of the RNA molecule and the corresponding promoter region. DHX37 uses ATP as a source of energy for its function. When DHX37 is activated, it begins to rotate the RNA molecule around the active site, leading to the formation of a stable RNA-DNA double helix.

DHX37 has been shown to play a role in various cellular processes, including DNA replication, transcription, and post-transcriptional modification [7,8]. It has also been shown to be involved in the regulation of gene expression by modifying the RNA secondary structure , which is critical for the translation of RNA into proteins [9,10].

Potential Drug Target

DHX37 has been identified as a potential drug target due to its unique mechanism of action and its involvement in various cellular processes. DHX37 functions as an RNA helicase, and targeting it could lead to new therapeutic approaches for various diseases.

One of the potential therapeutic approaches for DHX37 is inhibiting its function as an RNA helicase. This could be achieved by small molecules that are specific to DHX37's active site, leading to a reduction in the amount of RNA double-stranded. This would result in a reduction in the level of gene expression and potentially lead to a therapeutic intervention in diseases where DHX37 is over-expressed, such as cancer [11,12].

Another therapeutic potential approach for DHX37 is targeting its role in the regulation of gene expression by modifying the RNA secondary structure. This could be achieved by small molecules that alter DHX37's activity or its interaction with other RNA factors. This would result in a reduction in the level of gene expression and potentially lead to a therapeutic intervention in diseases where DHX37 is under-expressed, such as neurodegenerative diseases [13,14].

Potential Biomarkers

DHX37 has also been identified as a potential biomarker for various diseases. Its unique mechanism of action and its involvement in various cellular processes make it an attractive target for diagnostic tools.

One of the potential biomarkers for DHX37 is its ability to form RNA-DNA double-stranded. This can be used as a diagnostic tool for diseases

Protein Name: DEAH-box Helicase 37

Functions: ATP-binding RNA helicase that plays a role in maturation of the small ribosomal subunit in ribosome biogenesis (PubMed:30582406). Required for the release of the U3 snoRNP from pre-ribosomal particles (PubMed:30582406). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Plays a role in early testis development (PubMed:31287541, PubMed:31337883). Probably also plays a role in brain development (PubMed:31256877)

The "DHX37 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about DHX37 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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