DHX58: A Potential Drug Target for Various Diseases (G79132)

Target Name: DHX58

NCBI ID: G79132

DHX58

DHX58: A Potential Drug Target for Various Diseases

DHX58, also known as RNA helicase LGP2, is a protein that plays a crucial role in the regulation of gene expression in various organisms, including humans. It is a member of the LTR family of RNA helicases, which are responsible for the double-stranded RNA structure that is formed during transcription.

DHX58 is expressed in many different tissues and cells throughout the body, including the brain, heart, and gastrointestinal tract. It is involved in the regulation of gene expression, cell signaling, and DNA replication.

One of the key functions of DHX58 is its role in the regulation of microRNA (miRNA) levels. MiRNA are small non-coding RNAs that play a critical role in post-transcriptional gene regulation by binding to specific mRNAs and altering their stability or translation efficiency.

DHX58 is known to interact with miRNA-20, a miRNA that is involved in the regulation of various cellular processes, including cell growth, apoptosis, and inflammation. This interaction between DHX58 and miRNA-20 suggests that DHX58 may be a potential drug target or biomarker for the treatment of various diseases.

In addition to its role in miRNA regulation, DHX58 is also involved in the regulation of chromatin structure and gene expression. It has been shown to play a role in the regulation of DNA replication, and is therefore involved in the maintenance of genomic stability.

DHX58 is also involved in the regulation of cell signaling, specifically in the regulation of T cell development and function. T cells are a critical part of the immune system and play a key role in the regulation of immune responses to infection. DHX58 has been shown to be involved in the regulation of T cell development, and may be a potential drug target or biomarker for the treatment of autoimmune diseases.

DHX58 is also involved in the regulation of cell migration and invasion, processes that are critical for the development and progression of cancer. It has been shown to play a role in the regulation of cell adhesion and the invasive properties of cancer cells.

In conclusion, DHX58 is a protein that plays a critical role in the regulation of gene expression and various cellular processes in various organisms. Its interaction with miRNA-20 suggests that it may be a potential drug target or biomarker for the treatment of various diseases. Further research is needed to fully understand the role of DHX58 in cellular processes and its potential as a therapeutic target.

Protein Name: DExH-box Helicase 58

Functions: Acts as a regulator of RIGI and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1-dependent signaling events. Can have both negative and positive regulatory functions related to RIGI and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both. Its inhibitory action on RIG-I signaling may involve the following mechanisms: competition with RIGI for binding to the viral RNA, binding to RIGI and inhibiting its dimerization and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3). Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by RIGI and IFIH1/MDA5. Involved in the innate immune response to various RNA viruses and some DNA viruses such as poxviruses and coronavirus SARS-CoV-2, and also to the bacterial pathogen Listeria monocytogenes (PubMed:31256877). Can bind both ssRNA and dsRNA, with a higher affinity for dsRNA. Shows a preference to 5'-triphosphorylated RNA, although it can recognize RNA lacking a 5'-triphosphate

The "DHX58 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about DHX58 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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