Rh Blood Group Antigens: A Review of Dimeric Glycoproteins (G6006)

Target Name: RHCE

NCBI ID: G6006

RHCE

Rh Blood Group Antigens: A Review of Dimeric Glycoproteins

The Rh blood group antigen is a glycoprotein determined by the glycoprotein antigen on the surface of human red blood cells. Humans have four blood types, namely A, B, AB and O. These blood group antigens determine a person's blood type.

Rh blood group antigen is one of the most important antigens in the Rh blood group system. It is a dimer composed of two glycoprotein subunits, RhD and RhE. RhD and RhE subunits are linked together through non-covalent bonds to form a dimer. The RhD subunit is composed of two 伪-helices and two 尾-sheets, while the RhE subunit is composed of two 伪-helices.

Rh blood group antigens are immunogenic and can cause the immune system to produce an immune response. It is also antigenic and can react with the immune system, resulting in the production of specific antibodies. These antibodies can bind to the surface of RhD and RhE subunits, causing cell damage and the formation of immune complexes.

Due to the importance of Rh blood group antigens in the immune system, they are widely used as drug targets and biomarkers. Scientists have discovered many genes and proteins related to Rh blood group antigens, some of which are considered drug targets.

One protein related to the Rh blood group antigen is RhCG (CE), which is a glycoprotein determinant located on the surface of the RhD and RhE subunits. RhCG is a dimer composed of two 伪-helices and two 尾-sheets, and is related to the binding of RhD and RhE subunits.

RhCG is an antigen that can cause the immune system to produce an immune response. It can bind to antibodies, causing cell damage and the formation of immune complexes. In addition, some studies have shown that RhCG can be used as a potential drug target to treat certain diseases.

Another protein related to the Rh blood group antigen is RhSPA (SPA), which is a glycoprotein located on the surface of the RhD subunit. RhSPA is composed of two 伪-helices and two 尾-sheets and can bind to other proteins, causing cell damage and the formation of immune complexes.

RhSPA is also an antigen that can cause the immune system to produce an immune response. It can bind to antibodies, causing cell damage and the formation of immune complexes.

Protein Name: Rh Blood Group CcEe Antigens

Functions: May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
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•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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