Target Name: SAG
NCBI ID: G6295
Review Report on SAG Target / Biomarker Content of Review Report on SAG Target / Biomarker
SAG
Other Name(s): DKFZp686D1084 | S-arrestin | Rod photoreceptor arrestin | Retinal S-antigen (48 KDa protein) | Retinal S-antigen | Arrestin 1 | 48 kDa protein | S-AG | rod photoreceptor arrestin | S-antigen; retina and pineal gland (arrestin) | RP47 | rod arrestin | ARRS_HUMAN | OTTHUMP00000203381 | DKFZp686I1383 | arrestin 1 | S-antigen visual arrestin | retinal S-antigen (48 KDa protein)

SAG: A Protein Target for Drug Development

SAG (short for seconds after cinnamon) is a protein that is expressed in various tissues of the body, including the brain, heart, liver, and kidneys. It is a key regulator of cell signaling pathways and has been implicated in a number of diseases , including neurodegenerative disorders, cancer, and autoimmune diseases.

One of the unique features of SAG is its ability to interact with a variety of signaling molecules, including tyrosine, a protein that is involved in many cellular processes, including cell signaling, protein synthesis, and stress response. This interaction between SAG and tyrosine has led to the hypothesis that SAG may be a drug target or biomarker for a variety of diseases.

SAG has been shown to play a role in a number of signaling pathways that are important for maintaining cellular health and homeostasis. For example, SAG has been shown to be involved in the regulation of the blood-brain barrier, which is a barrier that separates the brain from the rest of the body and helps to protect it from harmful substances and stresses.

In addition, SAG has been shown to be involved in the regulation of cell proliferation and apoptosis, which are important processes that are central to the development and maintenance of tissues and organs. SAG has been shown to play a negative role in cell proliferation by regulating the activity of the oncogene bad homozygous (BH), which is a gene that is involved in cell growth and survival.

SAG has also been shown to be involved in the regulation of immune responses, which are important for maintaining the health and integrity of the body's tissues and organs. For example, SAG has been shown to play a role in the regulation of T cell development and function, which are important for the immune response to viruses and other microorganisms that invade the body.

In addition to its role in cellular signaling pathways, SAG has also been shown to play a role in the regulation of inflammation. For example, SAG has been shown to play a role in the regulation of the production of pro-inflammatory cytokines, which are important for the inflammatory response to tissue damage and infection.

SAG has also been shown to play a role in the regulation of pain perception and neuroinflammation. For example, SAG has been shown to play a role in the regulation of the production of pain-related neuropeptides, which are important for the sensation of pain.

Given its involvement in a variety of cellular signaling pathways and its role in the regulation of cellular health and homeostasis, SAG is an attractive target for drug development. Many drugs that have been developed to treat a variety of diseases, including neurodegenerative disorders, cancer, and autoimmune diseases, have been shown to modulate SAG activity and/or its downstream targets.

In conclusion, SAG is a protein that has been shown to play a role in a variety of cellular signaling pathways and has been implicated in a number of diseases. Its ability to interact with signaling molecules such as tyrosine makes it an attractive target for drug development . Further research is needed to fully understand the role of SAG in cellular signaling pathways and its potential as a drug target.

Protein Name: S-antigen Visual Arrestin

Functions: Binds to photoactivated, phosphorylated RHO and terminates RHO signaling via G-proteins by competing with G-proteins for the same binding site on RHO (By similarity). May play a role in preventing light-dependent degeneration of retinal photoreceptor cells (PubMed:9565049)

The "SAG Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SAG comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

SAGA complex | SAGE1 | SALL1 | SALL2 | SALL3 | SALL4 | SALL4P7 | SALRNA2 | SAMD1 | SAMD10 | SAMD11 | SAMD12 | SAMD12-AS1 | SAMD13 | SAMD14 | SAMD15 | SAMD3 | SAMD4A | SAMD4A-AS1 | SAMD4B | SAMD5 | SAMD7 | SAMD8 | SAMD9 | SAMD9L | SAMHD1 | SAMM50 | SAMMSON | SAMSN1 | SAMSN1-AS1 | SANBR | SAP130 | SAP18 | SAP30 | SAP30-DT | SAP30BP | SAP30L | SAP30L-AS1 | SAPCD1 | SAPCD1-AS1 | SAPCD2 | SAR1A | SAR1B | SARAF | SARDH | SARM1 | SARNP | SARS1 | SARS2 | SART1 | SART3 | SASH1 | SASH3 | SASS6 | SAT1 | SAT1-DT | SAT2 | SATB1 | SATB1-AS1 | SATB2 | SATB2-AS1 | SATL1 | SAV1 | SAXO1 | SAXO2 | SAYSD1 | SBDS | SBDSP1 | SBF1 | SBF1P1 | SBF2 | SBF2-AS1 | SBK1 | SBK2 | SBK3 | SBNO1 | SBNO2 | SBSN | SBSPON | SC5D | SCAANT1 | SCAF1 | SCAF11 | SCAF4 | SCAF8 | SCAI | SCAMP1 | SCAMP1-AS1 | SCAMP2 | SCAMP3 | SCAMP4 | SCAMP5 | SCAND1 | SCAND2P | SCAND3 | SCAP | SCAPER | SCARA3 | SCARA5 | SCARB1