CCL20: A Protein Interacting with C-C Motif and Potential Therapeutic Target

Target Name: CCL20

NCBI ID: G6364

CCL20

CCL20: A Protein Interacting with C-C Motif and Potential Therapeutic Target

CCL20, also known as chemokine (C-C motif) ligand 20, is a protein that is expressed in various cell types, including immune cells, cancer cells, and epithelial cells. It is a member of the chemokine family, which are a group of small signaling proteins that are involved in the immune response.

One of the unique features of CCL20 is its ability to interact with the C-C motif, which is a common structural motif found in many proteins that plays a role in their stability and functions. This motif is present in many different proteins, including enzymes, receptors, and signaling molecules.

CCL20's ability to interact with the C-C motif makes it an attractive target for researchers who are interested in finding new drugs or biomarkers for various diseases. This is because drugs that can interact with the C-C motif are likely to have broad effects on a variety of cellular processes, including signaling pathways, protein stability, and cell function.

In addition to its potential as a drug or biomarker, CCL20 is also a good candidate as a biomarker for certain types of cancer. For example, studies have shown that CCL20 levels are often elevated in various types of cancer, including breast, lung, and ovarian cancer. This suggests that CCL20 could be a useful diagnostic or predictive marker for these diseases.

Furthermore, CCL20 has also been shown to play a role in the regulation of cellular processes that are important for cancer progression. For example, studies have shown that CCL20 can inhibit the activity of cell signaling pathways that are involved in the development of cancer. This suggests that CCL20 may be a useful target for cancer therapies that are designed to inhibit these signaling pathways.

In conclusion, CCL20 is a protein that is expressed in various cell types and has been shown to interact with the C-C motif. Its potential as a drug or biomarker for various diseases makes it an attractive target for researchers who are interested in finding new treatments for these conditions. Further research is needed to fully understand the role of CCL20 in cellular processes and its potential as a therapeutic target.

Protein Name: C-C Motif Chemokine Ligand 20

Functions: Acts as a ligand for C-C chemokine receptor CCR6. Signals through binding and activation of CCR6 and induces a strong chemotactic response and mobilization of intracellular calcium ions (PubMed:11352563, PubMed:11035086, PubMed:20068036). The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and various autoimmune diseases (PubMed:21376174). CCL20 acts as a chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes (PubMed:9038201, PubMed:11352563). Involved in the recruitment of both the pro-inflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for optimal migration of thymic natural regulatory T cells (nTregs) and DN1 early thymocyte progenitor cells (By similarity). C-terminal processed forms have been shown to be equally chemotactically active for leukocytes (PubMed:11035086). Positively regulates sperm motility and chemotaxis via its binding to CCR6 which triggers Ca2+ mobilization in the sperm which is important for its motility (PubMed:23765988, PubMed:25122636). Inhibits proliferation of myeloid progenitors in colony formation assays (PubMed:9129037). May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells (By similarity). Possesses antibacterial activity towards E.coli ATCC 25922 and S.aureus ATCC 29213 (PubMed:12149255)

The "CCL20 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CCL20 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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