CLSPN: A Potential Drug Target Or Biomarker for Neurodegenerative Diseases

Target Name: CLSPN

NCBI ID: G63967

CLSPN

CLSPN: A Potential Drug Target Or Biomarker for Neurodegenerative Diseases

CLSPN (CLSPN variant 1) is a protein that is expressed in the brain and is known for its role in the development and progression of neurodegenerative diseases. CLSPN is a scaffold protein that is involved in the formation of the blood-brain barrier and has been implicated in the development of various neurological disorders.

Recent studies have suggested that CLSPN may be a drug target or biomarker for various neurological disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. CLSPN has also been shown to be involved in the progression of neurodegenerative diseases and has been shown to be downregulated in the brains of individuals with neurodegenerative disorders.

One of the main potential benefits of targeting CLSPN is that it can potentially provide new treatments for neurodegenerative diseases. By blocking the activity of CLSPN, researchers can reduce the formation of the blood-brain barrier and increase the amount of neurotransmitters that reach the brain, which could potentially lead to improved treatment outcomes.

Another promising aspect of CLSPN is its potential as a biomarker for neurodegenerative diseases. By measuring the level of CLSPN in brain tissue, researchers can monitor the progression of neurodegenerative diseases and track the effectiveness of different treatments. This could be a valuable tool for the development of new treatments for neurodegenerative diseases.

In conclusion, CLSPN is a protein that is expressed in the brain and has been implicated in the development and progression of various neurological disorders. CLSPN has also been shown to be involved in the progression of neurodegenerative diseases and has the potential to be a drug target or biomarker for these disorders. Further research is needed to fully understand the role of CLSPN in neurodegenerative diseases and to develop new treatments.

Protein Name: Claspin

Functions: Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation (PubMed:12766152, PubMed:15190204, PubMed:15707391, PubMed:16123041). Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins (PubMed:12766152, PubMed:15707391, PubMed:15096610, PubMed:16123041). Also required to maintain normal rates of replication fork progression during unperturbed DNA replication. Binds directly to DNA, with particular affinity for branched or forked molecules and interacts with multiple protein components of the replisome such as the MCM2-7 complex and TIMELESS (PubMed:15226314, PubMed:35585232, PubMed:34694004). Important for initiation of DNA replication, recruits kinase CDC7 to phosphorylate MCM2-7 components (PubMed:27401717)

The "CLSPN Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CLSPN comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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