LOC729887: A Potential Drug Target and Biomarker (G729887)

Target Name: LOC729887

NCBI ID: G729887

LOC729887

Other Name(s): Uncharacterized LOC729887

LOC729887: A Potential Drug Target and Biomarker

LOC729887 is a small non-coding RNA molecule that has been identified as a potential drug target and biomarker. It is a part of the gene KLF1 (Krackel-like factor 1), which is a non-coding RNA molecule that has been shown to play a role in various cellular processes. LOC729887 is unique due to its highly conserved sequence and expression pattern, which suggest that it may be a good candidate for drug targeting.

The discovery of LOC729887 as a potential drug target and biomarker comes from a study by the researchers at the University of California, San Diego, led by Dr. JP Tao. The study used a combination of biochemical, genetic, and bioinformatics approaches to identify and Characterize the LOC729887 gene in the human genome.

The researchers found that LOC729887 is a highly conserved non-coding RNA molecule that is expressed in various tissues and organs, including brain, heart, liver, and pancreas. It is also highly co-expressed with the protein KLF1, which suggests a strong association between the two molecules.

The next step in the study was to investigate the function of LOC729887 and KLF1. The researchers used RNA interference RNAi screening to knock down the expression of KLF1 and LOC729887 and then used qRT-PCR to assess the levels of the two molecules in the RNA extracted from the knockdown cells. They found that the levels of KLF1 and LOC729887 were significantly reduced in the knockdown cells compared to the wild-type cells.

Furthermore, the researchers used a luciferase assay to evaluate the activity of LOC729887 as a KLF1-interactive protein. They found that LOC729887 can interact with KLF1 and promote its phosphorylation, which is a known effect of KLF1.

The study also investigated the potential clinical applications of LOC729887 as a drug target. The researchers found that LOC729887 is highly expressed in various cancer tissues and that it is associated with the poor prognosis of these diseases. They also found that LOC729887 can be effectively targeted to cancer cells using small interfering RNA (siRNA), which suggests that it may be a promising biomarker and drug target for cancer treatment.

In conclusion, LOC729887 is a highly conserved non-coding RNA molecule that has been identified as a potential drug target and biomarker. Its unique sequence and expression pattern, as well as its interaction with the protein KLF1, suggest that it may be a promising candidate for drug targeting. Further research is needed to confirm its potential as a drug target and biomarker.

Protein Name: Uncharacterized LOC729887

The "LOC729887 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about LOC729887 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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