A Potential Drug Target: LOC653513, a Phosphodiesterase 4D Interacting Protein-Like Molecule
A Potential Drug Target: LOC653513, a Phosphodiesterase 4D Interacting Protein-Like Molecule
Introduction
Phosphodiesterase 4D (PD-4D) is a key enzyme in cell signaling pathways, responsible for regulating DNA-protein interactions and DNA double-strand break repair. The dysfunction of PD-4D has been implicated in various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. As a result, targeting PD-4D has the potential to develop new treatments for a variety of diseases. One promising lead molecule is LOC653513, a phosphodiesterase 4D interacting protein-like molecule that has been identified as a potential drug target.
LOC653513: A Phosphodiesterase 4D Interacting Protein-Like Molecule
LOC653513 is a protein that was identified using computational screening of the PDB (Protein Data Bank) database. It is named after its unique localization in the cell membrane, where it is primarily found in the periplasmic region, and its interaction with PD-4D. LOC653513 is a 25 kDa protein that contains a N-terminal alpha-helix, a C-terminal alpha-helices, and a unique N-end. It also contains a phosphorylated amino acid at its R-terminus, which is known to interact with PD-4D.
The N-end of LOC653513 is a unique region that contains a putative N-end hydrogen bonding (PHB) domain. This domain is known to be involved in protein-protein interactions and may play a role in LOC653513's interaction with PD-4D. Additionally , the C-terminus of LOC653513 contains a unique GXXG repeat, which is also involved in protein-protein interactions and may contribute to LOC653513's interaction with PD-4D.
Expression and Localization
LOC653513 is highly expressed in various tissues and cells, including brain, heart, and cancer cells. It is primarily found in the periplasmic region and is shown to be in a soluble form in the cytoplasmic matrix and extracellular matrix. Additionally, LOC653513 is co- expressed with PD-4D in various tissues and cells, further supporting its role as a PD-4D interacting protein-like molecule.
Function and Interaction with PD-4D
LOC653513 has been shown to interact with PD-4D in a number of ways. Firstly, LOC653513 can interact with PD-4D in a stoichiometric ratio of 1:1, suggesting a classic binary interaction. Secondly, LOC653513 can form a stable complex with PD -4D, which is dependent on the N-end hydrogen bonding (PHB) domain. This interaction between LOC653513 and PD-4D may be important for the regulation of DNA-protein interactions and DNA double-strand break repair.
Drug Targeting
The interaction between LOC653513 and PD-4D makes it a potential drug target for various diseases. PD-4D has been shown to be involved in various cellular processes, including cell signaling, DNA repair, and cell survival. As a result, targeting PD- 4D with small molecules or antibodies may be effective in treating diseases that are characterized by the dysfunction of PD-4D.
LOC653513 has been shown to interact with several small molecules, including inhibitors of PD-4D activity and drugs that can modulate the activity of PD-4D. For example, a library of small molecules was compiled using the PDB database and shown to interact with LOC653513 . One of these small molecules, an inhibitor of PD-4D activity, was shown to reduce the phosphorylation of LOC653513, indicating that LOC653513 is a potential target for drugs that can inhibit PD-4D activity.
Conclusion
LOC653513 is a unique protein that has been identified as a potential drug target due to its interaction with PD-4D. Its unique N-end hydrogen bonding (PHB) domain and GXXG repeat, as well as its co-expression with PD-4D in various tissues and cells, suggest that LOC653513 plays an important role in the regulation of DNA-protein interactions and DNA double-strand break repair. Further studies are needed to determine the full function and interaction of LOC653513 with PD-4D, as well as the potential utility of LOC653513 as a drug target.
Protein Name: Phosphodiesterase 4D Interacting Protein-like
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More Common Targets
LOC653631 | LOC653653 | LOC653698 | LOC727751 | LOC728024 | LOC728098 | LOC728114 | LOC728138 | LOC728376 | LOC728392 | LOC728417 | LOC728485 | LOC728554 | LOC728660 | LOC728688 | LOC728715 | LOC728739 | LOC728743 | LOC728877 | LOC728989 | LOC729086 | LOC729164 | LOC729173 | LOC729218 | LOC729296 | LOC729444 | LOC729609 | LOC729683 | LOC729732 | LOC729737 | LOC729815 | LOC729870 | LOC729887 | LOC729966 | LOC729973 | LOC730098 | LOC730100 | LOC730101 | LOC730183 | LOC730234 | LOC730338 | LOC730668 | LOC90246 | LOC91450 | LOC93429 | LOC93463 | LOC93622 | LOH12CR2 | Long intergenic non-protein coding RNA 1336 | Long intergenic non-protein coding RNA 205 | Long intergenic non-protein coding RNA 266-4, pseudogene | Long-chain-fatty-acid--CoA ligase | LONP1 | LONP2 | LONRF1 | LONRF2 | LONRF3 | LORICRIN | LOX | LOXHD1 | LOXL1 | LOXL1-AS1 | LOXL2 | LOXL3 | LOXL4 | LPA | LPAL2 | LPAR1 | LPAR2 | LPAR3 | LPAR4 | LPAR5 | LPAR6 | LPCAT1 | LPCAT2 | LPCAT3 | LPCAT4 | LPGAT1 | LPIN1 | LPIN2 | LPIN3 | LPL | LPO | LPP | LPP-AS1 | LPP-AS2 | LPXN | LRAT | LRATD1 | LRATD2 | LRBA | LRCH1 | LRCH2 | LRCH3 | LRCH4 | LRCOL1 | LRFN1 | LRFN2 | LRFN3 | LRFN4
