LOC646674: A Potential Drug Target and Biomarker for Single-Stranded DNA Binding Protein 4

LOC646674: A Potential Drug Target and Biomarker for Single-Stranded DNA Binding Protein 4

Introduction

Single-stranded DNA binding proteins (SSBs) are a crucial component of the immune system, as they help to recognize and neutralize foreign DNA in the body. One of the well-known SSBs is the protein LOC646674, which is a member of the family of DNA-binding proteins known as nucleotide-binding proteins (NBP). LOC646674 has been identified as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

Location and Structure

LOC646674 is a 21-kDa protein that is expressed in various tissues and organs, including muscle, heart, brain, and pancreas. It is highly conserved, with a calculated pI of 6.5 and a calculated hydrophobicity index of 126. LOC646674 is a monomer and has a unique molecular weight of 13.9 kDa.

Function and Interaction

LOC646674 is a NBP that uses a unique N-terminal domain to interact with DNA. This domain is composed of a short amino acid sequence (aa 1-4) and a long helix (aa 5-33) that contains a hydrophobic loop and a variable hydrophobic amino acid (aa 12). The N-terminal domain is responsible for the protein's ability to bind to DNA with high affinity and specificity.

LOC646674 has been shown to interact with various DNA templates, including human DNA and mouse DNA. Studies have shown that LOC646674 can form a stable complex with single-stranded DNA in a range of temperatures and under various conditions, such as high salt concentrations and high temperatures. These interactions suggest that LOC646674 may be a strong candidate for DNA-based therapeutics.

Drug Target Potential

LOC646674 has been identified as a potential drug target due to its unique ability to interact with DNA and its expressed levels in various tissues. The high affinity and specificity of LOC646674 for DNA make it an attractive target for small molecules, antibodies, or other therapeutic agents that can modulate its activity. Additionally, LOC646674 has been shown to be involved in various physiological processes, including DNA replication, repair, and gene expression, which makes it a potential target for drugs that can modulate these processes.

Biomarker Potential

LOC646674 has also been identified as a potential biomarker for various diseases. The expression of LOC646674 has been shown to be elevated in various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Additionally, LOC646674 has been shown to be involved in the development and progression of these diseases, which makes it a potential biomarker for their diagnosis and treatment.

Conclusion

LOC646674 is a unique and promising protein that has been identified as a potential drug target and biomarker for various diseases. Its ability to interact with DNA and its unique molecular structure make it an attractive target for small molecules, antibodies, or other therapeutic agents. Additionally , LOC646674 has been shown to be involved in various physiological processes, including DNA replication, repair, and gene expression, which makes it a potential target for drugs that can modulate these processes. Further research is needed to fully understand the potential of LOC646674 as a drug target and biomarker.

Protein Name: Single Stranded DNA Binding Protein 4 Pseudogene

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More Common Targets

LOC646736 | LOC646762 | LOC646813 | LOC646836 | LOC646853 | LOC646903 | LOC646934 | LOC646970 | LOC647115 | LOC647132 | LOC647481 | LOC649133 | LOC650157 | LOC650226 | LOC651536 | LOC652276 | LOC652608 | LOC653303 | LOC653503 | LOC653513 | LOC653631 | LOC653653 | LOC653698 | LOC727751 | LOC728024 | LOC728098 | LOC728114 | LOC728138 | LOC728376 | LOC728392 | LOC728417 | LOC728485 | LOC728554 | LOC728660 | LOC728688 | LOC728715 | LOC728739 | LOC728743 | LOC728877 | LOC728989 | LOC729086 | LOC729164 | LOC729173 | LOC729218 | LOC729296 | LOC729444 | LOC729609 | LOC729683 | LOC729732 | LOC729737 | LOC729815 | LOC729870 | LOC729887 | LOC729966 | LOC729973 | LOC730098 | LOC730100 | LOC730101 | LOC730183 | LOC730234 | LOC730338 | LOC730668 | LOC90246 | LOC91450 | LOC93429 | LOC93463 | LOC93622 | LOH12CR2 | Long intergenic non-protein coding RNA 1336 | Long intergenic non-protein coding RNA 205 | Long intergenic non-protein coding RNA 266-4, pseudogene | Long-chain-fatty-acid--CoA ligase | LONP1 | LONP2 | LONRF1 | LONRF2 | LONRF3 | LORICRIN | LOX | LOXHD1 | LOXL1 | LOXL1-AS1 | LOXL2 | LOXL3 | LOXL4 | LPA | LPAL2 | LPAR1 | LPAR2 | LPAR3 | LPAR4 | LPAR5 | LPAR6 | LPCAT1 | LPCAT2 | LPCAT3 | LPCAT4 | LPGAT1 | LPIN1 | LPIN2