TESK1: A Potential Drug Target and Biomarker for Specific Protein Kinase 1
TESK1: A Potential Drug Target and Biomarker for Specific Protein Kinase 1
Abstract:
The protein kinase 1 (ISOform 1) is a key regulator of cell proliferation and survival, and its dysfunction has been implicated in numerous diseases. TESK1, a dual specificity testis-specific protein kinase, has been identified as a potential drug target and biomarker for the treatment of various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. This article will provide an overview of TESK1, its functions, and potential therapeutic applications, as well as its potential as a drug target and biomarker.
Introduction:
The protein kinase 1 (ISOform 1) is a serine-thymidine-spikin protein that plays a crucial role in cell proliferation and survival. It is involved in numerous cellular processes, including cell growth, differentiation, angiogenesis, and DNA replication. The dysfunction of TESK1 has been implicated in various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.
TESK1: A Potential Drug Target
TESK1 has been identified as a potential drug target due to its involvement in multiple cellular processes that are associated with the development and progression of diseases. For example, TESK1 has been shown to be involved in cell proliferation, angiogenesis, and cancer progression. Its activation has been linked to the development of various types of cancer, including breast, ovarian, and prostate cancers.
In addition to its role in cancer, TESK1 has also been implicated in neurodegenerative diseases, including Alzheimer's and Parkinson's diseases. Its dysfunction has been linked to the misfolding and aggregation of T-cells, which contribute to the development of these diseases. 5).
TESK1: A Potential Biomarker
TESK1 has also been identified as a potential biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Its activation has been associated with the development and progression of these diseases, and its dysfunction has been linked to the development of various biomarkers ( 6).
For example, TESK1 has been shown to be involved in the development of various types of cancer, including breast, ovarian, and prostate cancers. Its dysfunction has been linked to the development of various biomarkers, including the expression of cancer-associated antigens (CAAs).
Conclusion:
TESK1 is a protein kinase that plays a crucial role in cell proliferation and survival. Its dysfunction has been implicated in various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. As a potential drug target and biomarker, TESK1 has the potential to be a valuable tool in the development and treatment of these diseases. Further research is needed to fully understand its functions and potential therapeutic applications.
Protein Name: Testis Associated Actin Remodelling Kinase 1
Functions: Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues (By similarity). Regulates the cellular cytoskeleton by enhancing actin stress fiber formation via phosphorylation of cofilin and by preventing microtubule breakdown via inhibition of TAOK1/MARKK kinase activity (By similarity). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity). Positively regulates integrin-mediated cell spreading, via phosphorylation of cofilin (PubMed:15584898). Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, suppression of ciliary vesicle directional trafficking to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (PubMed:25849865). Probably plays a central role at and after the meiotic phase of spermatogenesis (By similarity)
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• general information;
• protein structure and compound binding;
• protein biological mechanisms;
• its importance;
• the target screening and validation;
• expression level;
• disease relevance;
• drug resistance;
• related combination drugs;
• pharmacochemistry experiments;
• related patent analysis;
• advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai
More Common Targets
TESK2 | TESMIN | TESPA1 | TET1 | TET2 | TET2-AS1 | TET3 | Tetraspanin | TEX10 | TEX101 | TEX11 | TEX12 | TEX13A | TEX13B | TEX13C | TEX14 | TEX15 | TEX19 | TEX2 | TEX21P | TEX22 | TEX26 | TEX261 | TEX264 | TEX28 | TEX29 | TEX30 | TEX33 | TEX35 | TEX36 | TEX36-AS1 | TEX37 | TEX38 | TEX41 | TEX43 | TEX44 | TEX45 | TEX46 | TEX47 | TEX48 | TEX49 | TEX50 | TEX52 | TEX53 | TEX55 | TEX56P | TEX9 | TF | TFAM | TFAMP1 | TFAP2A | TFAP2A-AS1 | TFAP2A-AS2 | TFAP2B | TFAP2C | TFAP2D | TFAP2E | TFAP4 | TFB1M | TFB2M | TFCP2 | TFCP2L1 | TFDP1 | TFDP1P2 | TFDP2 | TFDP3 | TFE3 | TFEB | TFEC | TFF1 | TFF2 | TFF3 | TFG | TFIID Basal Transcription Factor Complex | TFIIIC2 complex | TFIP11 | TFIP11-DT | TFPI | TFPI2 | TFPT | TFR2 | TFRC | TG | TGDS | TGFA | TGFA-IT1 | TGFB1 | TGFB1I1 | TGFB2 | TGFB2-AS1 | TGFB3 | TGFBI | TGFBR1 | TGFBR2 | TGFBR3 | TGFBR3L | TGFBRAP1 | TGIF1 | TGIF2 | TGIF2-RAB5IF
