Traf3: A Protein Implicated in Various Physiological Processes and as A Potential Drug Target

Target Name: TRAF3

NCBI ID: G7187

TRAF3

Traf3: A Protein Implicated in Various Physiological Processes and as A Potential Drug Target

Traf3 (CAP-1) is a protein that is expressed in various tissues throughout the body, including the brain, heart, liver, and kidneys. It is a member of the superfamily of coiled-coil proteins, which are characterized by the presence of a coiled-coil domain. The function of Traf3 is not well understood, but it is thought to play a role in various physiological processes in the body.

One of the key functions of Traf3 is its role in the regulation of ion channels. These channels are responsible for the flow of electrical impulses through the cells, and they are critical for the proper functioning of many different tissues. Traf3 is thought to be involved in the regulation of the trafficking of ion channels to and from the cell surface, which is the process by which channels are added or removed from the surface of the cell.

Another function of Traf3 is its role in the regulation of cell signaling pathways. These pathways are responsible for the transduction of signals from the cell surface to the inside of the cell, and they are critical for the proper functioning of many different tissues. Traf3 is thought to be involved in the regulation of several different signaling pathways, including the TGF-β pathway and the Wnt pathway.

In addition to its role in ion channels and cell signaling pathways, Traf3 is also thought to be involved in the regulation of cellular processes that are important for the aging process. As the cells age, the number of organelles that are present in the cell decreases, which can lead to the dysfunction and death of the cell. Traf3 is thought to be involved in the regulation of the clearance of organelles from the cell, which is a process that is important for the aging process.

Traf3 is also a potential drug target, and several studies have suggested that it may be a useful target for the treatment of various diseases. For example, Traf3 has been shown to be involved in the regulation of the growth and differentiation of cancer cells, which suggests that it may be a useful target for the treatment of cancer. Additionally, Traf3 has been shown to be involved in the regulation of the development and progression of cardiovascular diseases, which suggests that it may be a useful target for the treatment of cardiovascular disease.

Overall, Traf3 is a protein that is expressed in various tissues throughout the body that is thought to play a role in the regulation of various physiological processes in the body. While more research is needed to fully understand the functions of Traf3, it is a potential drug target that could be useful for the treatment of a variety of diseases.

Protein Name: TNF Receptor Associated Factor 3

Functions: Cytoplasmic E3 ubiquitin ligase that regulates various signaling pathways, such as the NF-kappa-B, mitogen-activated protein kinase (MAPK) and interferon regulatory factor (IRF) pathways, and thus controls a lot of biological processes in both immune and non-immune cell types (PubMed:33148796, PubMed:33608556). In TLR and RLR signaling pathways, acts as an E3 ubiquitin ligase promoting the synthesis of 'Lys-63'-linked polyubiquitin chains on several substrates such as ASC that lead to the activation of the type I interferon response or the inflammasome (PubMed:25847972, PubMed:27980081). Following the activation of certain TLRs such as TLR4, acts as a negative NF-kappa-B regulator, possibly to avoid unregulated inflammatory response, and its degradation via 'Lys-48'-linked polyubiquitination is required for MAPK activation and production of inflammatory cytokines. Alternatively, when TLR4 orchestrates bacterial expulsion, TRAF3 undergoes 'Lys-33'-linked polyubiquitination and subsequently binds to RALGDS, mobilizing the exocyst complex to rapidly expel intracellular bacteria back for clearance (PubMed:27438768). Acts also as a constitutive negative regulator of the alternative NF-kappa-B pathway, which controls B-cell survival and lymphoid organ development. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14

The "TRAF3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TRAF3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets