Traf2: A Protein Implicated in Inflammation and Tissue Repair

Target Name: TRAF2

NCBI ID: G7186

TRAF2

Traf2: A Protein Implicated in Inflammation and Tissue Repair

Traf2 (Tumor Necrosis Factor-伪 Receptor Fusion Protein 2) is a protein that is expressed in various tissues of the body, including the immune system, and has been implicated in the regulation of inflammation and tissue repair. The protein is composed of two distinct chains, alpha chain and beta chain, that are held together by a disulfide bond. Traf2 has been shown to play a critical role in the regulation of inflammation and has been identified as a potential drug target in various diseases.

The alpha chain of Traf2 is a 21-kDa protein that is expressed in various tissues, including the liver, spleen, lung, heart, and muscle. It is composed of five transmembrane domains, including an extracellular domain, a transmembrane domain, an intracellular domain, and a cytoplasmic domain. The alpha chain of Traf2 is involved in the regulation of cellular signaling pathways, including the TGF-β pathway and the NF-kappa-B pathway.

The beta chain of Traf2 is a 14-kDa protein that is also expressed in various tissues, including the liver, spleen, lung, heart, and muscle. It is composed of four transmembrane domains, including an extracellular domain, a transmembrane domain, an intracellular domain, and a cytoplasmic domain. The beta chain of Traf2 is involved in the regulation of cellular signaling pathways, including the TGF-β pathway and the NF-kappa-B pathway.

Traf2 has been shown to play a critical role in the regulation of inflammation and has been identified as a potential drug target in various diseases. One of the mechanisms by which Traf2 regulates inflammation is through its role in the regulation of the NF-kappa-B pathway. The NF-kappa-B pathway is a complex signaling pathway that is involved in the regulation of inflammation, pain, and survival. Traf2 has been shown to play a critical role in the regulation of NF-kappa-B signaling by providing a negative signaling effect on the pathway.

Traf2 has also been shown to play a critical role in the regulation of cellular signaling pathways that are involved in tissue repair and regeneration. The TGF-β pathway is a critical signaling pathway that is involved in the regulation of cell proliferation, differentiation, and tissue regeneration. Traf2 has been shown to play a critical role in the regulation of TGF-β signaling by providing a negative signaling effect on the pathway.

In addition to its role in the regulation of inflammation and tissue repair, Traf2 has also been shown to play a critical role in the regulation of cellular signaling pathways that are involved in cell survival. The NF-kappa-B pathway is a complex signaling pathway that is involved in the regulation of cell survival and proliferation. Traf2 has been shown to play a critical role in the regulation of NF-kappa-B signaling by providing a negative signaling effect on the pathway.

Traf2 has also been shown to play a critical role in the regulation of cellular signaling pathways that are involved in cell adhesion and migration. The cadherin gene is a transmembrane protein that is involved in the regulation of cell adhesion and migration. Traf2 has been shown to play a critical role in the regulation of cadherin gene expression by providing a negative signaling effect on the gene.

Traf2 has also been shown to play a critical role in the regulation of cellular signaling pathways that are involved in cell signaling and inflammation. The NF-kappa-B pathway is a complex signaling pathway that is involved in the regulation of inflammation, pain, and survival. Traf2 has been shown to play a critical role in the regulation of NF-kappa-B signaling by providing a negative signaling effect on the pathway.

In conclusion, Traf2 is a protein that is involved in the regulation of

Protein Name: TNF Receptor Associated Factor 2

Functions: Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis (PubMed:22212761). Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. In complex with BIRC2 or BIRC3, promotes ubiquitination of IKBKE

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