TSG101: A Potential Drug Target and Biomarker for Tumor Invasion and Metastasis

Target Name: TSG101

NCBI ID: G7251

TSG101

TSG101: A Potential Drug Target and Biomarker for Tumor Invasion and Metastasis

Tumor invasion and metastasis are major causes of cancer-related mortality and disability. Approximately 80% of all cancer deaths are due to the development of metastasis. The tumor invasion and metastasis pathway is a complex process that involves the interplay of multiple factors, including the vascular system, the immune system, and the cell signaling pathways. TSG101, a gene located on chromosome 6p21.1, has been identified as a potential drug target and biomarker for tumor invasion and metastasis.

TSG101 is a non-coding RNA gene that is expressed in various tissues of the body, including the brain, heart, kidneys, and pancreas. The gene has been shown to be involved in the regulation of cell proliferation, differentiation, and survival. It is highly expressed in human cancer tissues and has been implicated in the development and progression of various types of cancer, including breast, ovarian, and colorectal cancers.

TSG101 has been shown to be involved in the regulation of the angiogenesis, which is the process by which new blood vessels form in response to increased blood flow to a particular area. During angiogenesis, TSG101 has been shown to be involved in the regulation of the vascular endothelial cell (VEC), which plays a key role in the formation of new blood vessels. The VEC is a specialized type of cell that has the ability to regulate the flow of blood to the body's tissues, and it is thought to be involved in the development and progression of many types of cancer.

In addition to its role in angiogenesis, TSG101 has also been shown to be involved in the regulation of the immune response. The immune response is a critical mechanism that helps the body to fight off infections and cancer. TSG101 has been shown to be involved in the regulation of the immune response by regulating the activity of a protein called TGF-β. TGF-β is a cytokine that plays a key role in the regulation of cell growth, differentiation, and survival.

TSG101 has also been shown to be involved in the regulation of the cell signaling pathways that are involved in cell proliferation and survival. It is highly expressed in various types of cancer tissues and has been shown to be involved in the regulation of the signaling pathways that are involved in the development and progression of cancer.

Despite the promising findings from these studies, more research is needed to fully understand the role of TSG101 in tumor invasion and metastasis. Further studies are needed to determine the exact mechanism by which TSG101 promotes tumor invasion and metastasis, and to identify potential drug targets and biomarkers for this process.

In conclusion, TSG101 is a gene that has been shown to be involved in the regulation of tumor invasion and metastasis. Further research is needed to fully understand the role of this gene in this process and to identify potential drug targets and biomarkers for this gene. If TSG101 is found to be involved in the regulation of tumor invasion and metastasis, it may be a valuable drug target for the treatment of various types of cancer.

Protein Name: Tumor Susceptibility 101

Functions: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). It may also play a role in the extracellular release of microvesicles that differ from the exosomes (PubMed:22315426)

The "TSG101 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TSG101 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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