UBE2B: A Protein Involved in Protein Stability, Localization, Interactions and Degradation

Target Name: UBE2B

NCBI ID: G7320

UBE2B

UBE2B: A Protein Involved in Protein Stability, Localization, Interactions and Degradation

Ubiquitin (UQ) is a protein that plays a critical role in the regulation of protein degradation. It is a large transmembrane protein that consists of a monomeric chain with a calculated molecular weight of 76 kDa. UQ is widely expressed in various cell types and is involved in the regulation of protein stability, localization, and interactions. One of the unique features of UQ is its ability to transport and deliver proteins to their target sites without being degraded by the ubiquitinases.

The ubiquitin carrier protein B (UBE2B) is a protein that is highly expressed in various cell types and is involved in the regulation of protein stability and localization. It is a 21 kDa protein that consists of a single transmembrane domain. UBE2B is highly conserved in various species, and its sequence is highly conserved between different species, indicating that it has a conserved function.

UBE2B functions as a carrier protein for various proteins, including histones, which are important components of the nucleosome. Histones are small proteins that play a critical role in the regulation of gene expression, DNA replication, and chromosome stability. UBE2B is known to interact with the histone modifications, which are important for the regulation of protein stability and localization.

UBE2B is also involved in the regulation of protein localization and interactions. It has been shown that UBE2B can interact with various protein partners, including histones, to form a complex that is involved in the regulation of protein stability and localization. UBE2B has been shown to play a critical role in the regulation of protein stability in various cell types, including cancer cells.

In addition to its role in the regulation of protein stability and localization, UBE2B is also involved in the regulation of protein interactions. It has been shown to interact with various proteins, including its own partner proteins, to form a complex that is involved in the regulation of protein stability and localization. UBE2B has been shown to play a critical role in the regulation of protein interactions in various cancer cell types, including cancer cells.

UBE2B is also involved in the regulation of protein degradation. It has been shown that UBE2B can interact with the ubiquitinases, which are proteins that are involved in the degradation of Ubiquitin. -proteasome system, which is involved in the degradation of Ubiquitin.

In conclusion, UBE2B is a protein that is involved in the regulation of protein stability and localization, as well as protein interactions and degradation. It is a conserved protein that plays a critical role in the regulation of various cellular processes. As a result, UBE2B may be a drug target or biomarker for various diseases, including cancer. Further research is needed to fully understand the functions of UBE2B and its potential as a drug or biomarker.

Protein Name: Ubiquitin Conjugating Enzyme E2 B

Functions: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. May be involved in neurite outgrowth

The "UBE2B Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about UBE2B comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets