Unlocking The Potential of Ubiquitin Enzyme 2N as A Drug Target and Biomarker

Target Name: UBE2N

NCBI ID: G7334

UBE2N

Unlocking The Potential of Ubiquitin Enzyme 2N as A Drug Target and Biomarker

Ubiquitin (U) is a protein that plays a crucial role in the regulation of various cellular processes, including DNA replication, RNA transcription, and cellular signaling pathways. UBE2N is a protein that belongs to the ubiquitin conjugating enzyme family 2 (UEF2) and is Known for its ability to convert ubiquitin into a flexible and water-soluble form, which can interact with a wide variety of protein targets.

UEF2N is a zinc-based enzyme that catalyzes the conversion of ubiquitin into a conformationally variable form of a water-added molecule. This process involves a series of intermediate steps, including the addition of a acetyl group to the N-terminus of ubiquitin, which creates a \"bendless-like\" structure. This unique structure allows UBE2N to interact with a wide variety of protein targets, making it a promising drug target and a potential biomarker for various diseases.

One of the key benefits of UBE2N is its ability to interact with a wide variety of protein targets. Because UBE2N can convert ubiquitin into a flexible and water-soluble form, it can interact with proteins that are either soluble in water or that are embedded in a hydrophobic environment. This makes UBE2N a versatile tool for the study of protein-protein interactions and a potential drug target.

UBE2N has been shown to interact with a wide range of protein targets, including transcription factors, signaling proteins, and cytoskeletal proteins. For example, studies have shown that UBE2N can interact with the transcription factors p53, p21, and p16, as well as with the cytoskeletal protein histone(3).

In addition to its ability to interact with protein targets, UBE2N also has been shown to play a role in the regulation of cellular processes. For example, UBE2N has been shown to be involved in the regulation of DNA replication, as well as the detoxification of environmental toxins.

UBE2N is also a potential biomarker for various diseases. Its ability to interact with a wide variety of protein targets makes it a promising tool for the study of protein-protein interactions and the development of new diagnostic tests. For example, UBE2N has been shown to be involved in the regulation of the development and progression of various diseases, including cancer.

In conclusion, UBE2N is a protein that plays a crucial role in the regulation of various cellular processes and has been shown to interact with a wide variety of protein targets. Its unique ability to convert ubiquitin into a flexible and water-soluble form makes it a promising drug target and a potential biomarker for various diseases. Further research is needed to fully understand the role of UBE2N in cellular processes and its potential as a drug target and biomarker.

Protein Name: Ubiquitin Conjugating Enzyme E2 N

Functions: The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly-ubiquitination of PCNA upon genotoxic stress, which is required for DNA repair. Appears to act together with E3 ligase RNF5 in the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes. Together with RNF135 and UB2V1, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIGI to activate the downstream signaling pathway that leads to interferon beta production (PubMed:28469175, PubMed:31006531). UBE2V1-UBE2N together with TRAF3IP2 E3 ubiquitin ligase mediate 'Lys-63'-linked polyubiquitination of TRAF6, a component of IL17A-mediated signaling pathway

The "UBE2N Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about UBE2N comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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