UBE4B: A Potential Drug Target and Biomarker (G10277)

Target Name: UBE4B

NCBI ID: G10277

UBE4B

UBE4B: A Potential Drug Target and Biomarker

Understanding the function and role of UBE4B in various organisms is of great interest, especially in the context of drug development. UBE4B, also known as homologous to yeast UFD2, is a gene that encodes a protein involved in the DNA damage response (DDR) pathway. The DDR pathway is a critical regulatory process that responds to DNA damage, including double-strand breaks, insertions, and deletions (SNPs) and is involved in maintaining cellular homeostasis, repair, and growth. UBE4B plays a crucial role in the regulation of this pathway, and its dysfunction has been implicated in various diseases, including cancer, neurodegenerative diseases, and developmental disorders. Therefore, targeting UBE4B has the potential to offer new therapeutic approaches for these diseases.

The UBE4B gene was first identified in the yeast species S cerevisiae as a gene that encodes a protein with homology to the human UBE4 gene, which is located on chromosome 6p21. UBE4 is a non-coding RNA molecule that is translated into a protein of approximately 21 kDa. The protein encoded by UBE4B is composed of multiple domains, including a N-terminal transmembrane domain, a T-loop region, a domain responsible for interacting with DNA, and a C-terminal domain that includes a putative G-protein-coupled receptor (GPCR) domain.

Functional studies have shown that UBE4B is involved in various cellular processes, including DNA replication, repair, and cell growth. UBE4B is a key regulator of the DDR pathway, as it is involved in the repair of double-strand breaks and insertions, as well as the regulation of DNA replication and cell growth.

One of the most significant functions of UBE4B is its role in DNA replication. UBE4B is known to be involved in the regulation of DNA replication by ensuring that the double-strand break is repaired before DNA replication can proceed. Specifically, UBE4B is involved in the repair of UV-induced double-strand breaks in the plasmid RAD21. Furthermore, UBE4B is also involved in the regulation of DNA replication in the presence of UV radiation, as demonstrated by experiments using cell culture models.

In addition to its role in DNA replication, UBE4B is also involved in the regulation of cell growth and growth arrest. UBE4B has been shown to play a role in regulating cell growth by ensuring that cells do not undergo an uncontrolled increase in size. Specifically, UBE4B is involved in the regulation of the level of the oncogene-associated gene (TGFF3), which encodes a transcription factor that regulates cell growth and cell cycle progression.

The dysfunction of UBE4B has been implicated in various diseases, including cancer, neurodegenerative diseases, and developmental disorders. For example, UBE4B is often overexpressed in various types of cancer, including breast, ovarian, and colorectal cancer. This overexpression is thought to contribute to the development of cancer-related phenotypes, including increased cell proliferation and the formation of tumors.

In addition to its involvement in cancer, UBE4B is also implicated in the development of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. UBE4B is thought to play a role in the regulation of neurodegenerative diseases by ensuring that the damaged DNA is properly repaired and that the cells are able to continue to function properly.

In conclusion, UBE4B is a gene that encodes a protein involved in the DNA damage response pathway. Its dysfunction has been implicated in various diseases, including cancer, neurodegenerative diseases, and developmental disorders. Therefore, targeting UBE4B has the potential to offer new therapeutic approaches for these diseases. Further research is needed to fully understand the functions

Protein Name: Ubiquitination Factor E4B

Functions: Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases (By similarity). May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase (By similarity). May regulate myosin assembly in striated muscles together with STUB1 and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation (PubMed:17369820)

The "UBE4B Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about UBE4B comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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